Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/130534
Title: | Purging behavior modulates the relationships of hormonal and behavioral parameters in women with eating disorders |
Author: | Grasa Martínez, Maria del Mar Villarreal, Laura Granero, Roser Vilà Baños, Ruth Penelo, Eva Agüera, Zaida Jiménez-Murcia, Susana Romero Romero, María del Mar Menchón Magriñá, José Manuel Remesar Betlloch, Xavier Fernández Aranda, Fernando Alemany, Marià, 1946- |
Keywords: | Trastorns de la conducta alimentària Hormones Dones Eating disorders Hormones Women |
Issue Date: | 14-May-2013 |
Publisher: | Karger |
Abstract: | Background/aims: There is ample consensus that there is a neurophysiological basis for the eating disorders (ED). Traits of personality translate into behavioural traits, purging being a well defined transversal example. Direct implication of steroid hormones on ED has been seldom studied, despite their effects on behaviour. Methods: After psychological interview analysis 57 ED female patients (31 purgative and 26 non-purgative), and 17 female controls were studied. Metabolic parameters and analysis of androgen, estrogen and glucocorticoid hormones were determined in parallel to the psychopathological profile (EDI-2 and SCL-90-R) and anthropometric measurements. Results: Psychometric tests showed clear differences between ED and controls, but there were few hormonal-metabolic significant differences. In purgative ED there were repeated (significant) positive correlations with CBG, and negative with SHBG, versus eating and general psychopathology. In non-purging, there were positive correlations for deoxycortisol, free fatty acids, albumin and negative for aspartate aminotransferase and psychopathological traits. Conclusion: The data hint at CBG/corticosteroids and sexual hormones/SHBG to be involved in purging behaviour and its psychopathology and severity scores. Correlations of selected psychometric data and the CBG/SHBG levels in purging may eventually result in clinical markers. This approach may provide additional clues for understanding the pathogenesis of the ED. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1159/000350473 |
It is part of: | Neuropsychobiology, 2013, vol. 67, num. 4, p. 230-240 |
URI: | http://hdl.handle.net/2445/130534 |
Related resource: | https://doi.org/10.1159/000350473 |
ISSN: | 0302-282X |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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