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http://hdl.handle.net/2445/130565
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DC Field | Value | Language |
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dc.contributor.author | Tejera Vaquerizo, Antonio | - |
dc.contributor.author | Nagore, Eduardo | - |
dc.contributor.author | Puig i Sardà, Susana | - |
dc.contributor.author | Robert, Caroline | - |
dc.contributor.author | Saiag, Philippe | - |
dc.contributor.author | Martín-Cuevas, Paula | - |
dc.contributor.author | Gallego, Elena | - |
dc.contributor.author | Herrera Acosta, Enrique | - |
dc.contributor.author | Aguilera, José | - |
dc.contributor.author | Malvehy, J. (Josep) | - |
dc.contributor.author | Carrera Álvarez, Cristina | - |
dc.contributor.author | Cavalcanti, Andrea | - |
dc.contributor.author | Rull, Ramón | - |
dc.contributor.author | Vilalta Solsona, Antonio | - |
dc.contributor.author | Lannoy, Emilie | - |
dc.contributor.author | Boutros, Celine | - |
dc.contributor.author | Benannoune, Naima | - |
dc.contributor.author | Tomasic, Gorana | - |
dc.contributor.author | Aegerte, Philippe | - |
dc.contributor.author | Vidal i Sicart, Sergi | - |
dc.contributor.author | Palou, Josep | - |
dc.contributor.author | Alós i Hernández, Llúcia | - |
dc.contributor.author | Requena, Celia | - |
dc.contributor.author | Traves, Víctor | - |
dc.contributor.author | Pla, Ángel | - |
dc.contributor.author | Bolumar, Isidro | - |
dc.contributor.author | Soriano, Virtudes | - |
dc.contributor.author | Guillén, Carlos | - |
dc.contributor.author | Herrera Ceballos, Enrique | - |
dc.date.accessioned | 2019-03-19T19:06:50Z | - |
dc.date.available | 2019-03-19T19:06:50Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0959-8049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130565 | - |
dc.description.abstract | Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion: Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma. | - |
dc.format.extent | 24 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejca.2015.05.023 | - |
dc.relation.ispartof | European Journal of Cancer, 2015, vol. 51, num. 13, p. 1780-1793 | - |
dc.relation.uri | https://doi.org/10.1016/j.ejca.2015.05.023 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Melanoma | - |
dc.subject.classification | Càncer de pell | - |
dc.subject.classification | Nodes limfàtics | - |
dc.subject.other | Melanoma | - |
dc.subject.other | Skin cancer | - |
dc.subject.other | Lymph nodes | - |
dc.title | Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 660002 | - |
dc.date.updated | 2019-03-19T19:06:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26072362 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Medicina) |
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660002.pdf | 747.89 kB | Adobe PDF | View/Open |
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