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DC Field | Value | Language |
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dc.contributor.author | Cillóniz, Catia | - |
dc.contributor.author | Liapikou, Adamantia | - |
dc.contributor.author | Martín Loeches, Manuel | - |
dc.contributor.author | Garcia Vidal, Carolina | - |
dc.contributor.author | Gabarrús, Albert | - |
dc.contributor.author | Ceccato, Adrian | - |
dc.contributor.author | Magdaleno, Daniel | - |
dc.contributor.author | Mensa Pueyo, Josep | - |
dc.contributor.author | Marco Reverté, Francesc | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.date.accessioned | 2019-03-21T13:49:20Z | - |
dc.date.available | 2019-03-21T13:49:20Z | - |
dc.date.issued | 2018-07-18 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130723 | - |
dc.description.abstract | Background There is only limited information on mortality over extended periods in hospitalized patients with pneumococcal community-acquired pneumonia (CAP). We aimed to evaluate the 30-day mortality and whether is changed over a 20-year period among immunocompetent adults hospitalized with pneumococcal CAP. Methods We conducted a retrospective observational study of data that were prospectively collected at the Hospital Clinic of Barcelona of all adult patients hospitalized with diagnosis of pneumococcal CAP over a 20-year period. To aid analysis, results were divided into four periods of 5 years each (1997-2001, 2002-2006, 2007-2011, 2012-2016). The primary outcome was 30-day mortality, but secondary outcomes included intensive care unit (ICU) admission, lengths of hospital and ICU-stays, ICU-mortality, and need of mechanical ventilation. Results From a cohort of 6,403 patients with CAP, we analyzed the data for 1,120 (17%) adults with a diagnosis of pneumococcal CAP. Over time, we observed decreases in the rates of alcohol consumption, smoking, influenza vaccination, and older patients (age ≥65 years), but increases in admissions to ICU and the need for non-invasive mechanical ventilation. The overall 30-day mortality rate was 8% (95% confidence interval, 6%-9%; 84 of 1,120 patients) and did not change significantly between periods (p = 0.33). Although, we observed a decrease in ICU-mortality comparing the first period (26%) to the second one (10%), statistical differences disappeared with adjustment (p0.38). Conclusion Over time, 30-day mortality of hospitalized pneumococcal CAP did not change significantly. Nor did it change in the propensity-adjusted multivariable analysis. Since mortality in pneumococcal pneumonia has remained unaltered for many years despite the availability of antimicrobial agents with proven in vitro activity, other non-antibiotic strategies should be investigated. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0200504 | - |
dc.relation.ispartof | PLoS One, 2018, vol. 13, num. 7, p. e0200504 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0200504 | - |
dc.rights | cc-by (c) Cillóniz, Catia et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Pneumònia adquirida a la comunitat | - |
dc.subject.classification | Septicèmia | - |
dc.subject.classification | Mortalitat | - |
dc.subject.classification | Malalts hospitalitzats | - |
dc.subject.other | Community-acquired pneumonia | - |
dc.subject.other | Septicemia | - |
dc.subject.other | Mortality | - |
dc.subject.other | Hospital patients | - |
dc.title | Twenty-year trend in mortality among hospitalized patients with pneumococcal community-acquired pneumonia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 686157 | - |
dc.date.updated | 2019-03-21T13:49:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30020995 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Medicina) |
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