Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/130725
Title: | A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma |
Author: | Armangué, Thaís Titulaer, Maarten J. Sabater, Lidia Pardo Moreno, Javier Gresa Arribas, Nuria Barbero Bordallo, Natalia Kelley, Gordon R. Kyung-Ha, Noh Takeda, Akitoshi Nagao, Takahiro Takahashi, Yukitoshi Lizcano, Angélica Carr, Aisling S. Graus Ribas, Francesc Dalmau Obrador, Josep |
Keywords: | Teratoma Encefalitis Tumors cerebrals Teratoma Encephalitis Brain tumors |
Issue Date: | 24-Apr-2013 |
Publisher: | Wiley-Liss |
Abstract: | Among 249 patients with teratoma‐associated encephalitis, 211 had N‐methyl‐D‐aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody‐positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody‐negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range = 12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/ana.23917 |
It is part of: | Annals of Neurology, 2013, vol. 75, num. 3, p. 435-441 |
URI: | http://hdl.handle.net/2445/130725 |
Related resource: | https://doi.org/10.1002/ana.23917 |
ISSN: | 0364-5134 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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