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http://hdl.handle.net/2445/130727
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DC Field | Value | Language |
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dc.contributor.author | García Rizo, Clemente | - |
dc.contributor.author | Kirkpatrick, Brian | - |
dc.contributor.author | Fernández-Egea, Emilio | - |
dc.contributor.author | Oliveira, Cristina | - |
dc.contributor.author | Bernardo Arroyo, Miquel | - |
dc.date.accessioned | 2019-03-21T18:00:29Z | - |
dc.date.available | 2019-03-21T18:00:29Z | - |
dc.date.issued | 2016-05-01 | - |
dc.identifier.issn | 0306-4530 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130727 | - |
dc.description.abstract | Objective: Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diabetes mellitus and cardiovascular disease; however pharmacological treatment might play a role. Material and methods: We compared a two hour glucose load in naïve patients at the onset of a serious mental illness (N = 102) (84 patients with a first episode of schizophrenia and related disorders, 6 with a first episode of bipolar I disorder and 12 with a first episode of major depression disorder) with another psychiatric diagnose, adjustment disorder (N = 17) and matched controls (N = 98). Results: Young patients with serious mental illness showed an increased two hour glucose load compared with adjustment disorder and the control group. Mean two hour glucose values [±standard deviation] were: for schizophrenia and related disorders 106.51 mg/dL [±32.0], for bipolar disorder 118.33 mg/dL [±34.3], for major depressive disorder 107.42 mg/dL [±34.5], for adjustment disorder 79.06 mg/dL[±24.4] and for the control group 82.11 mg/dL [±23.3] (p < 0.001). Conclusions: Our results reflect an abnormal metabolic pathway at the onset of the disease before any pharmacological treatment or other confounding factors might have taken place. Our results suggest a similar glycemic pathway in serious mental illnesses and the subsequent need of primary and secondary prevention strategies. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.psyneuen.2016.02.001 | - |
dc.relation.ispartof | Psychoneuroendocrinology, 2016, vol. 67, p. 70-75 | - |
dc.relation.uri | https://doi.org/10.1016/j.psyneuen.2016.02.001 | - |
dc.rights | cc-by-nc-nd (c) Elsevier Ltd, 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trastorn bipolar | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.classification | Depressió psíquica | - |
dc.subject.classification | Mortalitat | - |
dc.subject.other | Manic-depressive illness | - |
dc.subject.other | Schizophrenia | - |
dc.subject.other | Mental depression | - |
dc.subject.other | Mortality | - |
dc.title | Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 665724 | - |
dc.date.updated | 2019-03-21T18:00:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26878465 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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