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http://hdl.handle.net/2445/130889
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DC Field | Value | Language |
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dc.contributor.author | Montalbo Calafell, Ruth | - |
dc.contributor.author | Lozano Salvatella, Juan José | - |
dc.contributor.author | Izquierdo Reyes, Laura | - |
dc.contributor.author | Ingelmo-Torres, Mercedes | - |
dc.contributor.author | Baños, Carmen | - |
dc.contributor.author | Palou, Joan | - |
dc.contributor.author | Heijden, Antoine G. van der | - |
dc.contributor.author | Medina, Rafael | - |
dc.contributor.author | Schmidbauer, Joerg | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Ribal, María José | - |
dc.contributor.author | Alcaraz Asensio, Antonio | - |
dc.contributor.author | Mengual Brichs, Lourdes | - |
dc.date.accessioned | 2019-03-26T16:37:49Z | - |
dc.date.available | 2020-12-31T06:10:16Z | - |
dc.date.issued | 2019-02-07 | - |
dc.identifier.issn | 1931-5244 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130889 | - |
dc.description.abstract | This study aimed to improve our previous urine gene expression classifiers focusing on the detection of non-high-risk non-muscle-invasive bladder cancer (NMIBC), and develop a new classifier able to decrease the frequency of cystoscopies during bladder cancer (BC) patients' surveillance. A total of 597 urines from BC patients, controls and patients in follow-up for BC (PFBC) were included. The study has 3 phases. In the urinary biomarker discovery phase, 84 urines from BC and control patients were retrospectively included and analyzed by Ribonucleic Acid (RNA) sequencing. In the classifier development phase, a total of 132 selected genes from previous phase were evaluated by nCounter in 214 prospectively collected urines from PFBC (98 with tumor). A diagnostic classifier was generated by logistic regression. Finally, in the classifier validation phase, a multicentric and international cohort of 248 urines (134 BC and 114 nonrecurrent PFBC) was used to validate classifier performance. A total of 521 genes were found differentially expressed between non-high-risk NMIBC samples and all other groups (P < 0.05). An 8-gene diagnostic classifier with an area under curve (AUC) of 0.893 was developed. Validation of this classifier in a cohort of PFBC achieved an overall sensitivity (SN) and a negative predictive value (NPV) of 96% and 97%, respectively (AUC = 0.823). Notably, this accuracy was maintained in non-high-risk NMIBC group (SN = 94%; NPV = 98%). In conclusion, this 8-gene expression classifier has high SN and NPV in a real clinical scenario. The use of this classifier can reduce the number of follow-up cystoscopies in PFBC, although assessing its final place in clinical setting is necessary. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.trsl.2019.02.003 | - |
dc.relation.ispartof | Translational Research, The Journal of Laboratory and Clinical Medicine, 2019, vol. S1931-5244, num. 19, p. 30025-30028 | - |
dc.relation.uri | https://doi.org/10.1016/j.trsl.2019.02.003 | - |
dc.rights | cc-by-nc-nd (c) Central Society for Clinical Research , 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Diagnòstic per la imatge | - |
dc.subject.classification | Càncer de bufeta | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Diagnostic imaging | - |
dc.subject.other | Bladder cancer | - |
dc.subject.other | Gene expression | - |
dc.title | Ability of a urine gene expression classifier to reduce the number of follow up cystoscopies in bladder cancer patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 686534 | - |
dc.date.updated | 2019-03-26T16:37:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30771285 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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686534.pdf | 1.75 MB | Adobe PDF | View/Open |
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