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http://hdl.handle.net/2445/131928
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DC Field | Value | Language |
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dc.contributor.author | Izquierdo Reyes, Laura | - |
dc.contributor.author | Truan, David | - |
dc.contributor.author | Mengual Brichs, Lourdes | - |
dc.contributor.author | Mallofré i Gómez, Carme | - |
dc.contributor.author | Alcaraz Asensio, Antonio | - |
dc.date.accessioned | 2019-04-09T14:34:41Z | - |
dc.date.available | 2019-04-09T14:34:41Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | http://hdl.handle.net/2445/131928 | - |
dc.description.abstract | AIM: To assess HER-2 and p-AKT expression in upper urinary tract urothelial carcinoma (UTUC) in order to determine their value as prognostic factors of tumour progression and cancer-specific survival. PATIENTS AND METHODS: One hundred consecutive UTUC patients were retrospectively included, between 1990-2004, in 4 tissue microarrays for immunostaining. Median follow-up: 33.03 months. RESULTS: Positive HER-2 expression was found in 10 cases and cytoplasmic p-AKT expression in 84 cases; the expression intensity was strong: 30 cases, moderate: 28 and weak: 26. Nuclear p-AKT expression was found in 6 patients: 1 with strong, and 5 with moderate intensity. Nuclear p-AKT expression was an independent factor for tumour progression (HR=4.145, p=0.013), together with grade (HR=4.557, p=0.009) and stage (HR=2.085, p=0.003). In cancer-specific survival analysis, nuclear p-AKT expression (HR=4.268, p=0.017), together with grade (HR=5.214, p=0.035) and stage (HR=2.666, p=0.002) were identified as independent prognostic factors. CONCLUSION: Nuclear p-AKT expression together with stage and grade constitute independent prognostic factors for tumour progression and cancer-specific survival. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isformatof | Reproducció del document publicat a: http://ar.iiarjournals.org/content/30/6.toc | - |
dc.relation.ispartof | Anticancer Research, 2010, vol. 30, num. 6, p. 2439-2445 | - |
dc.rights | (c) International Institute of Anticancer Research, 2010 | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Malalties de l'aparell urinari | - |
dc.subject.classification | Tumors | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Diseases of the urinary organs | - |
dc.subject.other | Tumors | - |
dc.subject.other | Cancer | - |
dc.title | HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 603804 | - |
dc.date.updated | 2019-04-09T14:34:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 20651405 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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603804.pdf | 317.11 kB | Adobe PDF | View/Open |
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