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Title: | The BRICS (Bronchiectasis Radiologically Indexed CT Score): A Multicenter Study Score for Use in Idiopathic and Postinfective Bronchiectasis |
Author: | Bedi, Pallavi Chalmers, James D. Goeminne, Pieter C. Mai, Cindy Saravanamuthu, Pira Velu, Prasad Palani Cartlidge, Manjit K. Loebinger, Michael R Jacob, Joseph Kamal, Faisal Schembri, Nicola Aliberti, Stefano Hill, Uta Harrison, Mike Johnson, Christophe Screaton, Nicholas Haworth, Charles Polverino, Eva Rosales Mayor, Edmundo Torres Martí, Antoni Benegas Urteaga, Mariana Nelida Rossi, Adriano G. Patel, Dilip Hill, Adam T. |
Keywords: | Bronquitis Assaigs clínics Hospitals Malalties de l'aparell respiratori Bronchitis Clinical trials Hospitals Respiratory diseases |
Issue Date: | May-2018 |
Publisher: | American College of Chest Physicians |
Abstract: | Objectives The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis. Methods The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients. Results A total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV1, sputum purulence, and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operating-characteristic curve values for BRICS in the derivation cohort were 0.79 for percent predicted FEV1, 0.71 for sputum purulence, and 0.75 for hospital admissions per year; these values were 0.81, 0.70, and 0.70, respectively, in the validation cohort. Sputum free neutrophil elastase activity was significantly elevated in the group with emphysema on CT imaging. Conclusions A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.chest.2017.11.033 |
It is part of: | Chest, 2018, vol. 153, num. 5, p. 1177-1186 |
URI: | http://hdl.handle.net/2445/131951 |
Related resource: | https://doi.org/10.1016/j.chest.2017.11.033 |
ISSN: | 0012-3692 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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