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http://hdl.handle.net/2445/132333
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DC Field | Value | Language |
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dc.contributor.author | Feikin, Daniel R. | - |
dc.contributor.author | Kagucia, Eunice W. | - |
dc.contributor.author | Loo, Jennifer D. | - |
dc.contributor.author | Link-Gelles, Ruth | - |
dc.contributor.author | Puhan, Milo A. | - |
dc.contributor.author | Cherian, Thomas | - |
dc.contributor.author | Levine, Orin S. | - |
dc.contributor.author | Whitney,Cynthia G. | - |
dc.contributor.author | O'Brien, Katherine L. | - |
dc.contributor.author | Moore, Matthew R. | - |
dc.contributor.author | García García, Juan José | - |
dc.contributor.author | Serotype Replacement Study Group | - |
dc.date.accessioned | 2019-04-23T13:28:27Z | - |
dc.date.available | 2019-04-23T13:28:27Z | - |
dc.date.issued | 2013-09-24 | - |
dc.identifier.issn | 1549-1277 | - |
dc.identifier.uri | http://hdl.handle.net/2445/132333 | - |
dc.description.abstract | BACKGROUND: Vaccine-serotype (VT) invasive pneumococcal disease (IPD) rates declined substantially following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into national immunization programs. Increases in non-vaccine-serotype (NVT) IPD rates occurred in some sites, presumably representing serotype replacement. We used a standardized approach to describe serotype-specific IPD changes among multiple sites after PCV7 introduction. METHODS AND FINDINGS: Of 32 IPD surveillance datasets received, we identified 21 eligible databases with rate data ≥ 2 years before and ≥ 1 year after PCV7 introduction. Expected annual rates of IPD absent PCV7 introduction were estimated by extrapolation using either Poisson regression modeling of pre-PCV7 rates or averaging pre-PCV7 rates. To estimate whether changes in rates had occurred following PCV7 introduction, we calculated site specific rate ratios by dividing observed by expected IPD rates for each post-PCV7 year. We calculated summary rate ratios (RRs) using random effects meta-analysis. For children <5 years old, overall IPD decreased by year 1 post-PCV7 (RR 0.55, 95% CI 0.46-0.65) and remained relatively stable through year 7 (RR 0.49, 95% CI 0.35-0.68). Point estimates for VT IPD decreased annually through year 7 (RR 0.03, 95% CI 0.01-0.10), while NVT IPD increased (year 7 RR 2.81, 95% CI 2.12-3.71). Among adults, decreases in overall IPD also occurred but were smaller and more variable by site than among children. At year 7 after introduction, significant reductions were observed (18-49 year-olds [RR 0.52, 95% CI 0.29-0.91], 50-64 year-olds [RR 0.84, 95% CI 0.77-0.93], and ≥ 65 year-olds [RR 0.74, 95% CI 0.58-0.95]). CONCLUSIONS: Consistent and significant decreases in both overall and VT IPD in children occurred quickly and were sustained for 7 years after PCV7 introduction, supporting use of PCVs. Increases in NVT IPD occurred in most sites, with variable magnitude. These findings may not represent the experience in low-income countries or the effects after introduction of higher valency PCVs. High-quality, population-based surveillance of serotype-specific IPD rates is needed to monitor vaccine impact as more countries, including low-income countries, introduce PCVs and as higher valency PCVs are used. Please see later in the article for the Editors' Summary. | - |
dc.format.extent | 28 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pmed.1001517 | - |
dc.relation.ispartof | PLoS Medicine, 2013, vol. 10, num. 9, p. e1001517 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pmed.1001517 | - |
dc.rights | cc-by (c) Feikin, Daniel R. et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Pneumococs | - |
dc.subject.classification | Vacunes | - |
dc.subject.classification | Immunologia | - |
dc.subject.classification | Infants | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.subject.other | Vaccines | - |
dc.subject.other | Immunology | - |
dc.subject.other | Children | - |
dc.title | Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 664606 | - |
dc.date.updated | 2019-04-23T13:28:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24086113 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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File | Description | Size | Format | |
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664606.pdf | 3.32 MB | Adobe PDF | View/Open |
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