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Title: | Targeting prohibitins induces apoptosis in acute myeloid leukemia cells |
Author: | Pomares, Helena Palmeri, Claudia Mariela Iglesias i Serret, Daniel Moncunill Massaguer, Cristina Saura-Esteller, José Núñez-Vázquez, Sonia Gamundi, Enric Arnan, Montserrat Preciado Gallego, Sara Albericio Palomera, Fernando Lavilla Grífols, Rodolfo Pons i Irazazábal, Gabriel González Barca, Eva Cosialls Castel, Ana Mª Gil i Santano, Joan |
Keywords: | Càncer Leucèmia Farmacologia RNA Tumors Cancer Leukemia Pharmacology RNA Tumors |
Issue Date: | 10-Feb-2016 |
Publisher: | Impact Journals |
Abstract: | Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute myeloid leukemia (AML). Fluorizoline induced apoptosis in AML cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features. In addition, fluorizoline inhibited the clonogenic capacity and induced differentiation of AML cells. Fluorizoline increased the mRNA and protein levels of the pro-apoptotic BCL-2 family member NOXA both in cell lines and primary samples analyzed. These results suggest that targeting PHBs could be a new therapeutic strategy for AML |
Note: | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.11333 |
It is part of: | Oncotarget, 2016, vol. 7, num. 40, p. 64987-65000 |
URI: | http://hdl.handle.net/2445/132764 |
Related resource: | https://doi.org/10.18632/oncotarget.11333 |
ISSN: | 1949-2553 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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