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Title: Active Tensile Modulus of an Epithelial Monolayer
Author: Vincent, Romaric
Bazellières, Elsa
Pérez González, Carlos
Uroz, Marina
Serra Picamal, Xavier
Trepat Guixer, Xavier
Keywords: Cèl·lules epitelials
Estructura molecular
Epithelial cells
Molecular structure
Issue Date: 11-Dec-2015
Publisher: American Physical Society
Abstract: A general trait of cell monolayers is their ability to exert contractile stresses on their surroundings. The scaling laws that link such contractile stresses with the size and geometry of constituent cells remain largely unknown. In this Letter, we show that the active tension of an epithelial monolayer scales linearly with the size of the constituent cells, a surprisingly simple relationship. The slope of this relationship defines an active tensile modulus, which depends on the concentration of myosin and spans more than 2 orders of magnitude across cell types and molecular perturbations.
Note: Reproducció del document publicat a:
It is part of: Physical Review Letters, 2015, vol. 115, num. 24, p. 248103
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Biomedicina)
Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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