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Title: Pharmacogenetics of ugt genes in North African populations
Author: Gaibar, M.
Novillo, A.
Romero-Lorca, A.
Esteban i Torné, Maria Esther
Fernández-Santander, A.
Keywords: Enzims
Àfrica del Nord
North Africa
Issue Date: 31-Jul-2018
Publisher: Springer Nature
Abstract: Cytochrome P450 (CYP450), sulfotransferase (SULT), and glucuronidase (UGT) enzymes play roles in the phase I and phase II metabolism of most clinically prescribed drugs. As polymorphisms in these genes may alter enzyme activities, most prescribed drugs will differ in their efficacy and side effects. In prior work, we showed that besides polymorphisms in CYP450, those in SULT and UGT also give rise to different serum levels of some drug metabolites than detected in wild-type carriers of the genes [1]. [...]
Note: Reproducció del document publicat a:
It is part of: The Pharmacogenomics Journal, 2018, vol. 18, p. 609-612
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ISSN: 1470-269X
Appears in Collections:Articles publicats en revistes (Institut de Recerca de la Biodiversitat (IRBio))
Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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