Please use this identifier to cite or link to this item:
Title: Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin
Author: Novohradsky, Vojtech
Rovira, Anna
Hally, Cormac
Galindo Muñoz, Alex
Vigueras, Gloria
Gandioso, Albert
Svitelova, Marie
Bresolí-Obach, Roger
Kostrhunova, Hana
Markova, Lenka
Kasparkova, Jana
Nonell, Santi
Ruiz, José
Brabec, Viktor
Marchán Sancho, Vicente
Keywords: Cumarines
Cèl·lules canceroses
Cancer cells
Issue Date: 19-Mar-2019
Publisher: Wiley-VCH
Abstract: Although cyclometalated IrIII complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated IrIII complex conjugated to a far-red-emitting coumarin, IrIII-COUPY, is reported with highly favourable properties for cancer phototherapy. IrIII-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
Note: Versió postprint del document publicat a:
It is part of: Angewandte Chemie-International Edition, 2019, vol. 58, num. 19, p. 6311-6315
Related resource:
ISSN: 1433-7851
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
690079.pdf592.18 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.