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Title: Mammalian HP1 isoforms have specific roles in heterochromatin structure and organization
Author: Bosch Presegué, Laia
Raurell Vila, Helena
Thackray, Joshua K.
Casal, Carmen
González Merino, Jessica
Kane-Goldsmith, Noriko
Vizoso, Miguel
Brown, Jeremy
Gómez, Antonio
Ausió, Juan
Zimmermann, Timo
Esteller, Manel
Schotta, Gunnar
Singh, Prim B.
Serrano, Laura
Vaquero García, Alejandro
Keywords: Genoma humà
Human genome
Issue Date: 27-Nov-2017
Publisher: Elsevier
Abstract: HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α-/-, Hp1β-/-, and Hp1γ-/- MEFs show that HP1 proteins have both redundant and unique functions within pericentric heterochromatin (PCH) and also act globally throughout the genome. HP1α confines H4K20me3 and H3K27me3 to regions within PCH, while its absence results in a global hyper-compaction of chromatin associated with a specific pattern of mitotic defects. In contrast, HP1β is functionally associated with Suv4-20h2 and H4K20me3, and its loss induces global chromatin decompaction and an abnormal enrichment of CTCF in PCH and other genomic regions. Our work provides insight into the roles of HP1 proteins in heterochromatin structure and genome stability.
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It is part of: Cell Reports, 2017, vol. 21, num. 8, p. 2048-2057
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ISSN: 2211-1247
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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