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Title: Kv1.5 in the immune system: the good, the bad, or the ugly?
Author: Felipe Campo, Antonio
Soler Prat, Concepció
Comes i Beltrán, Núria
Keywords: Proteïnes
Canals de potassi
Sistema immunològic
Potassium channels
Immune system
Issue Date: 16-Oct-2010
Publisher: Frontiers Media
Abstract: For the last 20 years, knowledge of the physiological role of voltage-dependent potassium channels (Kv) in the immune system has grown exponentially. Leukocytes express a limited repertoire of Kv channels, which contribute to the membrane potential. These proteins are involved in the immune response and are therefore considered good pharmacological targets. Although there is a clear consensus about the physiological relevance of Kv1.3, the expression and the role of Kv1.5 are controversial. However, recent reports indicate that certain heteromeric Kv1.3/Kv1.5 associations may provide insight on Kv1.5. Here, we summarize what is known about this issue and highlight the role of Kv1.5 partnership interactions that could be responsible for this debate. The Kv1.3/Kv1.5 heterotetrameric composition of the channel and their possible differential associations with accessory regulatory proteins warrant further investigation.
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It is part of: Frontiers in Physiology, 2010, vol. 1, num. 152
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ISSN: 1664-042X
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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