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Title: In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma
Author: Pérez Salvia, Montserrat
Aldaba, Eneko
Vara, Yosu
Fabre, Myriam
Ferrer, Cristina
Masdeu, Carme
Zubia, Aizpea
San Sebastian, Eider
Otaegui, Dorleta
Llinàs-Arias, Pere
Rosselló-Tortella, Margalida
Berdasco, María
Moutinho, Cátia
Setién, Fernando
Villanueva Garatachea, Alberto
González Barca, Eva
Muncunill, Josep
Navarro, José-Tomás
Piris, Miguel A.
Cossio, Fernando P.
Esteller, Manel
Keywords: Inhibidors enzimàtics
Cèl·lules T
Enzyme inhibitors
T cells
Issue Date: Nov-2018
Publisher: Ferrata Storti Foundation
Abstract: Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the tumoral epigenome is characterized by both specific and general shifts in the DNA methylation and histone-modification landscapes.1 However, in contrast to genetic disruption, the effect of epigenetic modifications or marks may potentially be reversed by the use of drugs that target enzymes involved in adding, removing or signaling DNA methylation and histone modifications.1 This basic knowledge has been adopted into clinical practice, and inhibitors of histone deacetylases and DNA demethylating agents have been approved for use in the therapy of hematologic malignancies, such as cutaneous T-cell lymphoma and myelodysplastic syndrome, respectively.2 Other promising epigenetic drugs include inhibitors of histone methyltransferases,2 histone demethylases,2 histone kinases,3 and bromodomain proteins that interfere with the 'reading' of acetylated histone residues.
Note: Reproducció del document publicat a:
It is part of: Haematologica, 2018, vol. 103, num. 11, p. e537-e540
Related resource:
ISSN: 0390-6078
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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