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Title: Potential of adipose-derived stem cells in muscular regenerative therapies
Author: Forcales Fernàndez, Sonia-Vanina
Keywords: Teixit adipós
Regeneració (Biologia)
Cèl·lules mare
Trasplantament d'òrgans
Medicina regenerativa
Adipose tissues
Regeneration (Biology)
Stem cells
Transplantation of organs
Regenerative medicine
Issue Date: 13-Jul-2015
Publisher: Frontiers Media
Abstract: Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation to find new approaches that could boost regeneration of endogenous myogenic progenitor populations. In recent years, a lot of effort has been applied to purify, expand and manipulate adult stem cells from muscle tissue. However, this population of endogenous myogenic progenitors in adults is limited and their access is difficult and invasive. Therefore, other sources of stem cells with potential to regenerate muscles need to be examined. An excellent candidate could be a population of adult stromal cells within fat characterized by mesenchymal properties, which have been termed adipose-derived stem cells (ASCs). These progenitor adult stem cells have been successfully differentiated in vitro to osteogenic, chondrogenic, neurogenic and myogenic lineages. Autologous ASCs are multipotent and can be harvested with low morbidity; thus, they hold promise for a range of therapeutic applications. This review will summarize the use of ASCs in muscle regenerative approaches.
Note: Reproducció del document publicat a:
It is part of: Frontiers in Aging Neuroscience, 2015, vol. 7, p. 123
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ISSN: 1663-4365
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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