Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/134027
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dc.contributor.authorBonnin, Maria R.-
dc.contributor.authorMoragues, Carmen-
dc.contributor.authorNolla Solé, Joan Miquel-
dc.contributor.authorLirón, Francisco J.-
dc.contributor.authorRoig Escofet, D. (Daniel)-
dc.contributor.authorNavarro Moreno, Miguel Ángel-
dc.date.accessioned2019-05-28T12:48:22Z-
dc.date.available2019-05-28T12:48:22Z-
dc.date.issued1998-01-
dc.identifier.issn1434-6621-
dc.identifier.urihttp://hdl.handle.net/2445/134027-
dc.description.abstractWe evaluated circulating aminoterminal and carboxyterminal propeptides of type I procollagen and total alkaline phosphatase levels in eighty consecutive patients affected by Paget's disease of bone. We compared the biochemical data with the extent of bone disease calculated on the basis of the bone scintigraphic indices. Serum aminoterminal propeptide of type I procollagen levels were high in 77% of patients, serum carboxyterminal propeptide of type I procollagen levels in 22% and serum total alkaline phosphatase levels in 76%. We found significant correlations between the three markers studied. The three biochemical markers correlated significantly with the bone scintigraphic activity indices, but the highest correlation coefficient was between the aminoterminal propeptide and total alkaline phosphatase. We conclude that there is a discrepancy between serum levels of the propeptides studied in relation to Paget's disease of bone. The sensitivity of the carboxyterminal propeptide of type I procollagen in this disease is low. In contrast the aminoterminal propeptide may be as sensitive a marker for the evaluation of this disorder as total alkaline phosphatase, and in addition may be more specific.-
dc.format.extent3 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWalter de Gruyter-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1515/CCLM.1998.010-
dc.relation.ispartofClinical Chemistry and Laboratory Medicine, 1998, vol. 36, num. 1, p. 53-55-
dc.relation.urihttps://doi.org/10.1515/CCLM.1998.010-
dc.rights(c) Walter de Gruyter, 1998-
dc.sourceArticles publicats en revistes (Ciències Clíniques)-
dc.subject.classificationOsteïtis-
dc.subject.classificationSang-
dc.subject.classificationPèptids-
dc.subject.otherOsteitis-
dc.subject.otherBlood-
dc.subject.otherPeptides-
dc.titleEvaluation of circulating type I procollagen propeptides in patients with Paget's disease of bone-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec535309-
dc.date.updated2019-05-28T12:48:22Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid9594087-
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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