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Title: Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
Author: Illa Armengol, Míriam
Brito, Verónica
Pla, Laura
Eixarch Roca, Elisenda
Arbat-Plana, Ariadna
Batallé Bolaño, Dafnis
Muñoz-Moreno, Emma
Crispi Brillas, Fàtima
Udina, Esther
Figueras Retuerta, Francesc
Ginés Padrós, Silvia
Gratacós Solsona, Eduard
Keywords: Models animals en la investigació
Retard del creixement intrauterí
Animal models in research
Fetal growth retardation
Issue Date: 12-Oct-2017
Publisher: Karger
Abstract: INTRODUCTION: The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abnormalities in an IUGR rabbit model and the effects of early postnatal environmental enrichment (EE) were explored. MATERIALS AND METHODS: IUGR was surgically induced in one horn, whereas the contralateral one produced the controls. Postnatally, a subgroup of IUGR animals was housed in an enriched environment. Functional assessment was performed at the neonatal and long-term periods. At the long-term period, structural brain connectivity was evaluated by means of diffusion-weighted brain magnetic resonance imaging and by histological assessment focused on the hippocampus. RESULTS: IUGR animals displayed poorer functional results and presented altered whole-brain networks and decreased median fractional anisotropy in the hippocampus. Reduced density of dendritic spines and perineuronal nets from hippocampal neurons were also observed. Of note, IUGR animals exposed to enriched environment presented an improvement in terms of both function and structure. CONCLUSIONS: IUGR is associated with altered brain connectivity at the global and cellular level. A strategy based on early EE has the potential to restore the neurodevelopmental consequences of IUGR.
Note: Versió postprint del document publicat a:
It is part of: Fetal Diagnosis and Therapy, 2017, vol. 44, num. 3, p. 184-193
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ISSN: 1015-3837
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)

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