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http://hdl.handle.net/2445/134067
Title: | Fluoroquinolone resistance in penicillin-resistant streptococcus pneumoniae clones, Spain |
Author: | Campa, Adela G. de la Balsalobre, Luz Ardanuy Tisaire, María Carmen Fenoll, Asunción Pérez Trallero, Emilio Liñares Louzao, Josefina Spanish Pneumococcal Infection Study Network |
Keywords: | Resistència als medicaments Genètica Quinolones Farmacologia Farmacocinètica Pneumococs Espanya Drug resistance Genetics Quinolone antibacterial agents Pharmacology Pharmacokinetics Streptococcus pneumonia Spain |
Issue Date: | Oct-2004 |
Publisher: | Centers for Disease Control and Prevention |
Abstract: | Among 2,882 Streptococcus pneumoniae sent to the Spanish Reference Laboratory during 2002, 75 (2.6%) were ciprofloxacin-resistant. Resistance was associated with older patients (3.9% in adults and 7.2% in patients > or =65 years of age), with isolation from noninvasive sites (4.3% vs. 1.0%), and with penicillin and macrolide resistance. Among 14 low-level resistant (MIC 4-8 microg/mL) strains, 1 had a fluoroquinolone efflux phenotype, and 13 showed single ParC changes. The 61 high-level ciprofloxacin-resistant (MIC > or =16 microg/mL) strains showed either two or three changes at ParC, ParE, and GyrA. Resistance was acquired either by point mutation (70 strains) or by recombination with viridans streptococci (4 strains) at the topoisomerase II genes. Although 36 pulsed-field gel electrophoresis patterns were observed, 5 international multiresistant clones (Spain23F-1, Spain6B-2, Spain9V-3, Spain14-5 and Sweden15A-25) accounted for 35 (46.7%) of the ciprofloxacin-resistant strains. Continuous surveillance is needed to prevent the dissemination of these clones. |
Note: | Reproducció del document publicat a: https://wwwnc.cdc.gov/eid/articles/issue/10/10/table-of-contents |
It is part of: | Emerging Infectious Diseases, 2004, vol. 10, num. 10, p. 1751-1759 |
URI: | http://hdl.handle.net/2445/134067 |
ISSN: | 1080-6040 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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