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Title: Toxoplasmosis in transplant recipients, Europe, 2010-2014
Author: Robert-Gangneux, Florence
Meroni, Valeria
Dupont, Damien
Botterel, Françoise
Aguado, José María
Brenier-Pinchart, Marie-Pierre
Accoceberry, Isabelle
Akan, Hamdi
Abbate, Isabella
Boggian, Katia
Bruschi, Fabrizio
Carratalà, Jordi
David, Miruna D.
Drgona, Lubos
Djurkovic-Djakovic, Olgica
Fariñas, María Carmen
Genco, Francesca
Gkrania-Klotsas, Effrossyni
Groll, Andreas H.
Guy, Edward
Hirzel, Cédric
Khanna, Nina
Kurt, Özgür
Junie, Lia Monica
Lazzarotto, Tiziana
Len, Óscar
Mueller, Nicolas J.
Muñoz, Patricia
Plana, Zoi Dorothea
Roilides, Emmanuel
Stajner, Tijana
Van Delden, Christian
Villena, Isabelle
Pelloux, Hervé
Manuel, Oriol
Keywords: Toxoplasma
Issue Date: Aug-2018
Publisher: Centers for Disease Control and Prevention
Abstract: Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.
Note: Reproducció del document publicat a:
It is part of: Emerging Infectious Diseases, 2018, vol. 24, num. 8, p. 1497-1504
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ISSN: 1080-6040
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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