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Title: | A randomised study on the clinical progress of high-risk elective major gastrointestinal surgery patients treated with olive oil-based parenteral nutrition with or without a fish oil supplement |
Author: | Badia Tahull, Maria Bella Llop Talaverón, Josep Manuel Leiva Badosa, Elisabet Biondo, Sebastián Farrán Teixidor, Leandre Ramon Torrell, Josep M. (Josep Maria) Jódar Masanés, Ramón José |
Keywords: | Agents antiinfecciosos Cirurgia Malalties del tracte gastrointestinal Alimentació parenteral Ús terapèutic Emulsions Olis de peix Cura postoperatòria Programes de prevenció Anti-infective agents Surgery Gastrointestinal system diseases Parenteral feeding Therapeutic use Emulsions Fish oils Postoperative care Prevention programs |
Issue Date: | Sep-2010 |
Publisher: | Cambridge University Press |
Abstract: | n-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a standard olive oil (OO) emulsion. The secondary aims were the assessment of anti-inflammatory response and evaluation of tolerance and safety of these emulsions. A prospective, randomised, double-blind study was performed in patients requiring at least 5 d of PN. An isoenergetic and isoproteic formula was administered: group A received OO alone, while group B received OO that was partially replaced with FO (16.6 %, w/w). End points were outcome measures (mortality, sepsis, infection, hospitalisation days and PN duration), inflammatory response (C-reactive protein (CRP), prealbumin and leucocytes) and safety (TAG and glucose metabolism, and liver and kidney function). Statistical analysis was done using Student's t test and Fisher's exact test (P < 0.05). Twenty-seven patients were evaluated, with thirteen patients receiving FO. In this group, a significantly lower incidence of infections was found (23.1 v. 78.6 %, P = 0.007). CRP, prealbumin and leucocytes were not significantly different between the groups. There were no differences in safety parameters. We conclude that high-risk surgical patients receiving FO-supplemented PN for 5 d present a lower incidence of infection. Emulsions were safe and well tolerated. |
Note: | Reproducció del document publicat a: https://doi.org/10.1017/S0007114510001066 |
It is part of: | British Journal of Nutrition, 2010, vol. 104, num. 5, p. 737-741 |
URI: | https://hdl.handle.net/2445/134285 |
Related resource: | https://doi.org/10.1017/S0007114510001066 |
ISSN: | 0007-1145 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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