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http://hdl.handle.net/2445/134420
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DC Field | Value | Language |
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dc.contributor.author | Tom, Robby Zachariah | - |
dc.contributor.author | Sjögren, Rasmus J. O. | - |
dc.contributor.author | Vieira, Elaine | - |
dc.contributor.author | Glund, Stephan | - |
dc.contributor.author | Iglesias-Gutiérrez, Eduardo | - |
dc.contributor.author | García-Roves, Pablo M. (Pablo Miguel) | - |
dc.contributor.author | Myers Jr, Martin G. | - |
dc.contributor.author | Björnholm, Marie | - |
dc.date.accessioned | 2019-06-03T13:53:28Z | - |
dc.date.available | 2019-06-03T13:53:28Z | - |
dc.date.issued | 2011-06-01 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/2445/134420 | - |
dc.description.abstract | Leptin regulates food intake and energy expenditure by activating the long form of the leptin receptor (LepRb). Leptin also regulates glucose homeostasis by improving whole-body insulin sensitivity, but the mechanism remains undefined. Leptin action is mediated by phosphorylation of several tyrosine residues on LepRb. LepRb-Tyr985 plays an important role in the attenuation of LepRb signaling. We determined the contribution of LepRb-Tyr985-mediated signals to leptin action on insulin sensitivity using LepRb-Tyr985 mutant mice (l/l mice). Glucose tolerance and whole-body insulin-mediated glucose utilization were determined in wild-type (+/+) and l/l mice. Glucose tolerance was unaltered between female +/+ and l/l mice but enhanced in the male l/l mice. Serum insulin concentration was decreased at baseline and 15 min after a glucose injection in female l/l vs. +/+ mice (P < 0.05) but unaltered in the male l/l mice. However, basal and insulin-stimulated glucose transport in isolated soleus and extensor digitorum longus muscle was similar between +/+ and l/l mice, indicating skeletal muscle insulin sensitivity in vitro was not enhanced. Moreover, euglycemic-hyperinsulinemic clamps reveal hepatic, rather than peripheral, insulin sensitivity is enhanced in female l/l mice, whereas male l/l mice display both improved hepatic and peripheral insulin sensitivity. In conclusion, signals emanating from leptin receptor Tyr985 control hepatic insulin sensitivity in both female and male l/l mice. Lack of LepRb-Tyr985 signaling enhances whole-body insulin sensitivity partly through increased insulin action on the suppression of hepatic glucose production. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Association for the Study of Internal Secretions | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1210/en.2010-0040 | - |
dc.relation.ispartof | Endocrinology, 2011, vol. 152, num. 6, p. 2237-2246 | - |
dc.relation.uri | https://doi.org/10.1210/en.2010-0040 | - |
dc.rights | (c) Association for the Study of Internal Secretions, 2011 | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Insulina | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.classification | Leptina | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.other | Insulin | - |
dc.subject.other | Liver diseases | - |
dc.subject.other | Leptin | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.title | Increased hepatic insulin sensitivity in mice lacking inhibitory leptin receptor signals | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 650526 | - |
dc.date.updated | 2019-06-03T13:53:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21521753 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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650526.pdf | 1.13 MB | Adobe PDF | View/Open |
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