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http://hdl.handle.net/2445/134962
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DC Field | Value | Language |
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dc.contributor.author | Dobaño, Carlota, 1969- | - |
dc.contributor.author | Sanz Ródenas, Héctor | - |
dc.contributor.author | Sorgho, Hermann | - |
dc.contributor.author | Dosoo, David | - |
dc.contributor.author | Mpina, Maximilian | - |
dc.contributor.author | Ubillos, Itziar | - |
dc.contributor.author | Aguilar, Ruth | - |
dc.contributor.author | Ford, Tom | - |
dc.contributor.author | Díez-Padrisa, Núria | - |
dc.contributor.author | Williams, Nana Aba | - |
dc.contributor.author | Ayestaran, Aintzane | - |
dc.contributor.author | Traore, Ousmane | - |
dc.contributor.author | Nhabomba, Augusto J. | - |
dc.contributor.author | Jairoce, Chenjerai | - |
dc.contributor.author | Waitumbi, John | - |
dc.contributor.author | Agnandji, Selidji Todagbe | - |
dc.contributor.author | Kariuki, Simon | - |
dc.contributor.author | Abdulla, Salim | - |
dc.contributor.author | Aponte, John J. | - |
dc.contributor.author | Mordmüller, Benjamin | - |
dc.contributor.author | Asante, Kwaku Poku | - |
dc.contributor.author | Owusu-Agyei, Seth | - |
dc.contributor.author | Tinto, Halidou | - |
dc.contributor.author | Campo, Joseph J. | - |
dc.contributor.author | Moncunill, Gemma | - |
dc.contributor.author | Gyan, Ben | - |
dc.contributor.author | Valim, Clarissa | - |
dc.contributor.author | Daubenberger, Claudia | - |
dc.date.accessioned | 2019-06-12T14:27:01Z | - |
dc.date.available | 2019-06-12T14:27:01Z | - |
dc.date.issued | 2019-05-15 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/134962 | - |
dc.description.abstract | RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p\xE2\x80\x89<\xE2\x80\x890.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between means), and higher concentrations and avidities in children than infants (p\xE2\x80\x89<\xE2\x80\x890.001). Baseline CSP IgG levels are elevated in malaria cases than controls (p\xE2\x80\x89<\xE2\x80\x890.001). Both, IgG magnitude to NANP (hazard ratio [95% confidence interval] 0.61 [0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90]) post-vaccination are significantly associated with vaccine efficacy. IgG avidity to the C-terminus emerges as a significant contributor to RTS,S/AS01E-mediated protection. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/s41467-019-10195-z | - |
dc.relation.ispartof | Nature Communications, 2019, vol. 10 | - |
dc.relation.uri | http://dx.doi.org/10.1038/s41467-019-10195-z | - |
dc.rights | cc by (c) Dobaño et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Vacuna de la malària | - |
dc.subject.classification | Infants | - |
dc.subject.classification | Africans | - |
dc.subject.other | Malaria vaccine | - |
dc.subject.other | Children | - |
dc.title | Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2019-05-27T09:03:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31092823 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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File | Description | Size | Format | |
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Doba_oC_Nat_Commun_2019.pdf | 998.85 kB | Adobe PDF | View/Open |
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