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DC Field | Value | Language |
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dc.contributor.author | López Medrano, Francisco | - |
dc.contributor.author | Fernández Ruiz, Mario | - |
dc.contributor.author | Silva, José Tiago | - |
dc.contributor.author | Carver, Peggy L. | - |
dc.contributor.author | Delden, Christian van | - |
dc.contributor.author | Merino, Esperanza | - |
dc.contributor.author | Pérez Sáez, María José | - |
dc.contributor.author | Montero, María Milagro | - |
dc.contributor.author | Coussement, Julien | - |
dc.contributor.author | Abreu Mazzolin, Milene de | - |
dc.contributor.author | Cervera, Carlos | - |
dc.contributor.author | Santos, Lidia | - |
dc.contributor.author | Sabé, Nuria | - |
dc.contributor.author | Scemla, Anne | - |
dc.contributor.author | Cordero, Elisa | - |
dc.contributor.author | Cruzado Vega, Leónidas | - |
dc.contributor.author | Martín Moreno, Paloma Leticia | - |
dc.contributor.author | Len, Óscar | - |
dc.contributor.author | Rudas, Eddison | - |
dc.contributor.author | Ponce de León, Alfredo | - |
dc.contributor.author | Arriola, Mariano | - |
dc.contributor.author | Lauzurica, Ricardo | - |
dc.contributor.author | David, Miruna D. | - |
dc.contributor.author | González Rico, Claudia | - |
dc.contributor.author | Henríquez Palop, Fernando | - |
dc.contributor.author | Fortún, Jesús | - |
dc.contributor.author | Nucci, Marcio | - |
dc.contributor.author | Manuel, Oriol | - |
dc.contributor.author | Paño Pardo, José Ramón | - |
dc.contributor.author | Montejo, Miguel | - |
dc.contributor.author | Vena, Antonio | - |
dc.contributor.author | Sánchez Sobrino, Beatriz | - |
dc.contributor.author | Mazuecos, María A. | - |
dc.contributor.author | Pascual, Julio (Pascual Santos) | - |
dc.contributor.author | Horcajada Gallego, Juan Pablo | - |
dc.contributor.author | Lecompte, Thanh | - |
dc.contributor.author | Moreno Camacho, Ma. Asunción | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | Blanes, Marino | - |
dc.contributor.author | Perelló Carrascosa, Manuel | - |
dc.contributor.author | Muñoz, Patricia | - |
dc.contributor.author | Andrés, Amado | - |
dc.contributor.author | Aguado, José María | - |
dc.contributor.author | Spanish Network for Research in Infectious Diseases (REIPI) | - |
dc.contributor.author | Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) | - |
dc.contributor.author | Study Group for Infections in Compromised Hosts (ESGICH) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) | - |
dc.contributor.author | Swiss Transplant Cohort Study (STCS) | - |
dc.date.accessioned | 2019-06-13T09:46:02Z | - |
dc.date.available | 2019-06-13T09:46:02Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1198-743X | - |
dc.identifier.uri | http://hdl.handle.net/2445/134999 | - |
dc.description.abstract | OBJECTIVES: To assess the risk factors for development of late-onset invasive pulmonary aspergillosis (IPA) after kidney transplantation (KT). METHODS: We performed a multinational case-control study that retrospectively recruited 112 KT recipients diagnosed with IPA between 2000 and 2013. Controls were matched (1:1 ratio) by centre and date of transplantation. Immunosuppression-related events (IREs) included the occurrence of non-ventilator-associated pneumonia, tuberculosis, cytomegalovirus disease, and/or de novo malignancy. RESULTS: We identified 61 cases of late (>180 days after transplantation) IPA from 24 participating centres (accounting for 54.5% (61/112) of all cases included in the overall study). Most diagnoses (54.1% (33/61)) were established within the first 36 post-transplant months, although five cases occurred more than 10 years after transplantation. Overall mortality among cases was 47.5% (29/61). Compared with controls, cases were significantly older (p 0.010) and more likely to have pre-transplant chronic obstructive pulmonary disease (p 0.001) and a diagnosis of bloodstream infection (p 0.016) and IRE (p <0.001) within the 6 months prior to the onset of late IPA. After multivariate adjustment, previous occurrence of IRE (OR 19.26; 95% CI 2.07-179.46; p 0.009) was identified as an independent risk factor for late IPA. CONCLUSION: More than half of IPA cases after KT occur beyond the sixth month, with some of them presenting very late. Late IPA entails a poor prognosis. We identified some risk factors that could help the clinician to delimit the subgroup of KT recipients at the highest risk for late IPA. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | European Society of Clinical Microbiology and Infectious Diseases | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.cmi.2017.06.016 | - |
dc.relation.ispartof | Clinical Microbiology and Infection, 2018, vol. 24, num. 2, p. 192-198 | - |
dc.relation.uri | https://doi.org/10.1016/j.cmi.2017.06.016 | - |
dc.rights | (c) López Medrano, Francisco et al., 2018 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.classification | Malalties de l'aparell respiratori | - |
dc.subject.classification | Aspergil·losi | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Risk factors in diseases | - |
dc.subject.other | Respiratory diseases | - |
dc.subject.other | Aspergillosis | - |
dc.title | Multinational case-control study of risk factors for the development of late invasive pulmonary aspergillosis following kidney transplantation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 676789 | - |
dc.date.updated | 2019-06-13T09:46:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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676789.pdf | 341.58 kB | Adobe PDF | View/Open |
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