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DC Field | Value | Language |
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dc.contributor.author | Nacher, Victor | - |
dc.contributor.author | Raurell, Mercè | - |
dc.contributor.author | Merino Rodríguez, Francisco | - |
dc.contributor.author | Aranda, Olga | - |
dc.contributor.author | Soler Ramon, Joan | - |
dc.contributor.author | Montanya Mias, Eduard | - |
dc.date.accessioned | 2019-06-13T13:58:48Z | - |
dc.date.available | 2019-06-13T13:58:48Z | - |
dc.date.issued | 1996-11 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/2445/135007 | - |
dc.description.abstract | We determined beta-cell replication and mass in basal and stimulated conditions in long-term transplanted islets. Three groups of streptozocin-induced diabetic Lewis rats were transplanted with 1,000 islets (500 islets under left and right kidney capsules). At 2 (Tx-2), 5 (Tx-5), or 9 (Tx-9) months after transplantation, one of the two grafts (basal) was harvested; 14 days later, the contralateral graft (stimulated) was also harvested. Normoglycemia was achieved and maintained in all transplanted rats, although the capacity to respond to a glucose challenge deteriorated slightly 9 months after transplantation. Beta-cell replication remained stable in Tx-2, Tx-5, and Tx-9 basal grafts and was similar to replication in a control group of nontransplanted rats (0.28 +/- 0.06%); replication increased in Tx-2 (0.90 +/- 0.23%, P < 0.05) and Tx-9 (0.72 +/- 0.09%, P < 0.05) stimulated grafts. Beta-cell mass in basal grafts was similar to the initially transplanted mass (1.24 +/- 0.06 mg) and increased in stimulated grafts in Tx-2 (1.91 +/- 0.38 mg, P < 0.05) and Tx-5 (1.73 +/- 0.27 mg, P = 0.01) groups, compared with basal grafts, and in Tx-2 and Tx-9 groups (1.92 +/- 0.30 mg, P < 0.05), compared with initially transplanted mass. Therefore, beta-cell replication and mass were preserved up to 9 months after syngeneic transplantation, and beta-cells maintained the capacity to respond to increased metabolic demand, suggesting that replication is not a limiting factor in the survival of transplanted islets. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Diabetes Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2337/diab.45.11.1541 | - |
dc.relation.ispartof | Diabetes, 1996, vol. 45, num. 11, p. 1541-1546 | - |
dc.relation.uri | https://doi.org/10.2337/diab.45.11.1541 | - |
dc.rights | cc-by-nc-nd (c) American Diabetes Association, 1996 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Diabetis | - |
dc.subject.classification | Cirurgia | - |
dc.subject.classification | Illots de Langerhans | - |
dc.subject.classification | Patologia | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Rates (Animals de laboratori) | - |
dc.subject.other | Diabetes | - |
dc.subject.other | Surgery | - |
dc.subject.other | Islands of Langerhans | - |
dc.subject.other | Pathology | - |
dc.subject.other | Physiology | - |
dc.subject.other | Rats as laboratory animals | - |
dc.title | Beta-cell growth and mass are preserved in long-term syngeneic islet transplantation in streptozocin-induced diabetic Lewis rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 537246 | - |
dc.date.updated | 2019-06-13T13:58:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 8866559 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
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537246.pdf | 1.03 MB | Adobe PDF | View/Open |
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