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http://hdl.handle.net/2445/135024
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DC Field | Value | Language |
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dc.contributor.author | Montanya Mias, Eduard | - |
dc.contributor.author | Nacher, Victor | - |
dc.contributor.author | Biarnés Costa, Montse | - |
dc.contributor.author | Soler Ramon, Joan | - |
dc.date.accessioned | 2019-06-13T14:53:32Z | - |
dc.date.available | 2019-06-13T14:53:32Z | - |
dc.date.issued | 2000-08 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/2445/135024 | - |
dc.description.abstract | We determined the beta-cell replicative rate, beta-cell apoptosis, cross-sectional beta-cell area, and pancreatic beta-cell mass throughout the entire postweaning lifespan (months 1, 3, 7, 10, 15, and 20) of Lewis rats. Beta-cell replication was progressively reduced in the initial months of life but remained stable after month 7 (month 1, 0.99 +/- 0.10%; month 3, 0.24 +/- 0.04%; month 7, 0.12 +/- 0.02%; month 10, 0.14 +/- 0.02%; month 15, 0.10 +/- 0.03%; month 20, 0.13 +/- 0.03%; analysis of variance [ANOVA], P < 0.001). Beta-cell apoptosis was low and did not change significantly from month 1 to 20 of life. Cross-sectional area of individual beta-cells increased progressively in the initial months, remained stable from month 7 to 15, and increased again on month 20. The estimated number of beta-cells per pancreas, calculated as the ratio of total beta-cell mass to individual beta-cell mass, tripled from month 1 to 7 but did not change significantly thereafter. Beta-cell mass increased approximately 8 times from month 1 to 20 (month 1, 2.04 +/- 0.28 mg; month 20, 15.5 +/- 2.32 mg; ANOVA, P < 0.001) and showed a strong and significant linear correlation with body weight (r = 0.98, P < 0.001). In summary, we have shown that beta-cell replication was maintained throughout the lifespan in normal rats, clearly establishing that the beta-cell birth rate does not fall to 0, even in very old rats. Beta-cell mass increased throughout the lifespan, closely matching the increment in total body weight at any time point. This increment was selective for beta-cells, since the growth of the endocrine non-beta-cell mass was limited to the initial months of life. Both beta-cell hypertrophy and hyperplasia contributed to increased beta-cell mass in young animals, but only beta-cell hypertrophy was responsible for the increased beta-cell mass found in old animals. This study provides a global perspective for understanding the dynamics of beta-cell mass in young, adult, and aged animals. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Diabetes Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2337/diabetes.49.8.1341 | - |
dc.relation.ispartof | Diabetes, 2000, vol. 49, num. 8, p. 1341-1346 | - |
dc.relation.uri | https://doi.org/10.2337/diabetes.49.8.1341 | - |
dc.rights | cc-by-nc-nd (c) American Diabetes Association, 2000 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Envelliment | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Pes corporal | - |
dc.subject.classification | Illots de Langerhans | - |
dc.subject.classification | Anatomia | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.other | Aging | - |
dc.subject.other | Physiology | - |
dc.subject.other | Body weight | - |
dc.subject.other | Islands of Langerhans | - |
dc.subject.other | Anatomy | - |
dc.subject.other | B cells | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.title | Linear correlation between beta cell mass and body wight throughout the lifespan in Lewis rats: role of beta cell hyperplasia and hypertrophy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 537258 | - |
dc.date.updated | 2019-06-13T14:53:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 10923635 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
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537258.pdf | 56.48 kB | Adobe PDF | View/Open |
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