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http://hdl.handle.net/2445/135189
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DC Field | Value | Language |
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dc.contributor.author | Rocafort, Muntsa | - |
dc.contributor.author | Noguera Julian, Marc | - |
dc.contributor.author | Rivera, Javier | - |
dc.contributor.author | Pastor, Lucía | - |
dc.contributor.author | Guillén, Yolanda | - |
dc.contributor.author | Langhorst, Jost | - |
dc.contributor.author | Parera, Mariona | - |
dc.contributor.author | Mandomando, Inácio | - |
dc.contributor.author | Carrillo, Jorge | - |
dc.contributor.author | Urrea, Victor | - |
dc.contributor.author | Rodríguez, Cristina | - |
dc.contributor.author | Casadellà, Maria | - |
dc.contributor.author | Calle, María Luz | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Blanco, Julià | - |
dc.contributor.author | Naniche, Denise | - |
dc.contributor.author | Paredes, Roger | - |
dc.date.accessioned | 2019-06-18T15:10:30Z | - |
dc.date.available | 2019-06-18T15:10:30Z | - |
dc.date.issued | 2019-05-11 | - |
dc.identifier.issn | 2049-2618 | - |
dc.identifier.uri | http://hdl.handle.net/2445/135189 | - |
dc.description.abstract | Background: In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9–18 months and compared them with 98 chronically HIV-1- infected subjects treated with antiretrovirals (n = 27) or not (n = 71). Results: We show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriome—featuring depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridium—previously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects. Conclusions: Recent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s40168-019-0687-5 | - |
dc.relation.ispartof | Microbiome, 2019, vol. 7, num. 73 | - |
dc.relation.uri | http://dx.doi.org/10.1186/s40168-019-0687-5 | - |
dc.rights | cc by (c) Rocafort et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Microbiota | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.other | HIV infections | - |
dc.title | Evolution of the gut microbiome following acute HIV-1 infection | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2019-05-27T09:03:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31078141 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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RocafortM_Microbiome_2019.pdf | 6.17 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License