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Title: Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination
Author: Greenhouse, Bryan
Daily, Jennifer
Guinovart, Caterina
Goncalves, Bronner
Beeson, James G.
Bell, David
Chang, Michelle A.
Cohen, Justin M.
Ding, Xavier C.
Domingo, Gonzalo
Eisele, Thomas P.
Lammie, Patrick J.
Mayor Aparicio, Alfredo Gabriel
Merienne, Nicolas
Monteiro, Wuelton Marcelo
Painter, John
Rodríguez, Isabel
White, Michael T.
Drakeley, Chris
Mueller, Ivo
Malaria Serology Convening
Keywords: Malària
Issue Date: 7-Jun-2019
Publisher: Bill and Melinda Gates Foundation
Abstract: Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response; and testing and treating P. vivax hypnozoite carriers.
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It is part of: Gates Open Research, 2019, vol. 3 , num. 131
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ISSN: 2572-4754
Appears in Collections:Articles publicats en revistes (ISGlobal)

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