Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/137239
Title: | Kidins220 correlates with tau in Alzheimer's disease brain and cerebrospinal fluid |
Author: | Gamir Morralla, Andrea Belbin, Olivia Fortea Ormaechea, Juan Alcolea, Daniel Ferrer, Isidro (Ferrer Abizanda) Lleó Bisa, Alberto Iglesias, Teresa |
Keywords: | Malaltia d'Alzheimer Líquid cefalorraquidi Patologia Cervell Metabolisme Proteïnes de membrana Alzheimer's disease Cerebrospinal fluid Pathology Brain Metabolism Membrane proteins |
Issue Date: | Aug-2017 |
Publisher: | IOS Press |
Abstract: | Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrospinal fluid (CSF) of controls and AD patients. Only the N-terminal antibody showed a positive correlation between Kidins220 and phosphorylated tau in AD brains. Using this antibody, Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. This study highlights the potential of Kidins220 as a CSF biomarker in AD. |
Note: | Versió postprint del document publicat a: https://doi.org/10.3233/JAD-160639 |
It is part of: | Journal of Alzheimer's Disease, 2017, vol. 55, num. 4, p. 1327-1333 |
URI: | http://hdl.handle.net/2445/137239 |
Related resource: | https://doi.org/10.3233/JAD-160639 |
ISSN: | 1387-2877 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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