Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/137285
Title: | Specific small-RNA signatures in the amygdala at premotor and motor stages of Parkinson's disease revealed by deep sequencing analysis |
Author: | Pantano, Lorena Friedlaender, Marc R. Escaramís Babiano, Geòrgia Lizano, Esther Pallarès Albanell, Joan Ferrer, Isidro (Ferrer Abizanda) Estivill, Xavier, 1955- Martí Puig, Eulàlia |
Keywords: | Malaltia de Parkinson RNA Parkinson's disease RNA |
Issue Date: | 1-Mar-2016 |
Publisher: | Oxford University Press |
Abstract: | Motivation: Most computational tools for small non-coding RNAs (sRNA) sequencing data analysis focus in microRNAs (miRNAs), overlooking other types of sRNAs that show multi-mapping hits. Here, we have developed a pipeline to non-redundantly quantify all types of sRNAs, and extract patterns of expression in biologically defined groups. We have used our tool to characterize and profile sRNAs in post-mortem brain samples of control individuals and Parkinson's disease (PD) cases at early-premotor and late-symptomatic stages. Results: Clusters of co-expressed sRNAs mapping onto tRNAs significantly separated premotor and motor cases from controls. A similar result was obtained using a matrix of miRNAs slightly varying in sequence (isomiRs). The present framework revealed sRNA alterations at premotor stages of PD, which might reflect initial pathogenic perturbations. This tool may be useful to discover sRNA expression patterns linked to different biological conditions. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1093/bioinformatics/btv632 |
It is part of: | Bioinformatics, 2016, vol. 32, num. 5, p. 673-681 |
URI: | http://hdl.handle.net/2445/137285 |
Related resource: | https://doi.org/10.1093/bioinformatics/btv632 |
ISSN: | 1367-4803 |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Biomedicina) |
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