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Title: Variation in brain DNA
Author: Avila, Jesús
Gómez Ramos, Alberto
Soriano García, Eduardo
Keywords: Sistema nerviós
Malaltia d'Alzheimer
Mutació (Biologia)
Nervous system
Alzheimer's disease
Mutation (Biology)
Issue Date: 25-Nov-2014
Publisher: Frontiers Media
Abstract: It is assumed that DNA sequences are conserved in the diverse cell types present in a multicellular organism like the human being. Thus, in order to compare the sequences in the genome of DNA from different individuals, nucleic acid is commonly isolated from a single tissue. In this regard, blood cells are widely used for this purpose because of their availability. Thus blood DNA has been used to study genetic familiar diseases that affect other tissues and organs, such as the liver, heart, and brain. While this approach is valid for the identification of familial diseases in which mutations are present in parental germinal cells and, therefore, in all the cells of a given organism, it is not suitable to identify sporadic diseases in which mutations might occur in specific somatic cells. This review addresses somatic DNA variations in different tissues or cells (mainly in the brain) of single individuals and discusses whether the dogma of DNA invariance between cell types is indeed correct. We will also discuss how single nucleotide somatic variations arise, focusing on the presence of specific DNA mutations in the brain.
Note: Reproducció del document publicat a:
It is part of: Frontiers in Aging Neuroscience, 2014, vol. 6, p. 323
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ISSN: 1663-4365
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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