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http://hdl.handle.net/2445/138523
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DC Field | Value | Language |
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dc.contributor.author | Maffei, Mariano, 1985- | - |
dc.contributor.author | Arbesú Andrés, Miguel | - |
dc.contributor.author | Le Roux, Anabel-Lise | - |
dc.contributor.author | Amata, Irene | - |
dc.contributor.author | Roche, Serge | - |
dc.contributor.author | Pons Vallès, Miquel | - |
dc.date.accessioned | 2019-07-29T12:01:54Z | - |
dc.date.available | 2019-07-29T12:01:54Z | - |
dc.date.issued | 2015-04-23 | - |
dc.identifier.issn | 0969-2126 | - |
dc.identifier.uri | http://hdl.handle.net/2445/138523 | - |
dc.description.abstract | Regulation of c-Src activity by the intrinsically disordered Unique domain has been recently demonstrated. However, its connection with the classical regulatory mechanisms is still missing. Here we show that the Unique domain is part of a long loop closed by the interaction of the SH4 and SH3 domains. The conformational freedom of the Unique domain is further restricted through direct contacts with SH3 that are allosterically modulated by binding of a poly-proline ligand in the presence and in the absence of lipids. Our results highlight the scaffolding role of the SH3 domain for the c-Src N-terminal intrinsically disordered regions and suggest a connection between the regulatory mechanisms involving the SH3 and Unique domains. | - |
dc.format.extent | 42 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.str.2015.03.009 | - |
dc.relation.ispartof | Structure, 2015, vol. 23, num. 5, p. 893-902 | - |
dc.relation.uri | https://doi.org/10.1016/j.str.2015.03.009 | - |
dc.rights | (c) Elsevier Ltd, 2015 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Models moleculars | - |
dc.subject.classification | Lípids | - |
dc.subject.classification | Proteïnes quinases | - |
dc.subject.classification | Homologia (Biologia) | - |
dc.subject.other | Molecular models | - |
dc.subject.other | Lipids | - |
dc.subject.other | Protein kinases | - |
dc.subject.other | Homology (Biology) | - |
dc.title | The SH3 domain acts as a scaffold for the N-terminal intrinsically disordered regions of c-Src | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 651266 | - |
dc.date.updated | 2019-07-29T12:01:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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651266.pdf | 1.56 MB | Adobe PDF | View/Open |
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