Please use this identifier to cite or link to this item:
Title: Potential role of adult stem cells in obstructive sleep apnea
Author: Almendros López, Isaac
Carreras, Alba
Montserrat Canal, José Ma.
Gozal, David
Navajas Navarro, Daniel
Farré Ventura, Ramon
Keywords: Síndromes d'apnea del son
Cèl·lules mare
Sleep apnea syndromes
Stem cells
Issue Date: 11-Jul-2012
Publisher: Frontiers Media
Abstract: Adult stem cells are undifferentiated cells that can be mobilized from the bone marrow or other organs, home into injured tissues, and differentiate into different cell phenotypes to serve in a repairing capacity. Furthermore, these cells can respond to inflammation and oxidative stress by exhibiting immunomodulatory properties. The protective and reparative roles of mesenchymal stem cells (MSCs), very small embryonic-like stem cells (VSELs), and endothelial progenitor cells (EPCs) have primarily been examined and characterized in auto-immune and cardiovascular diseases. Obstructive sleep apnea (OSA) is a very prevalent disease (4-5% of adult population and 2-3% of children) characterized by an abnormal increase in upper airway collapsibility. Recurrent airway obstructions elicit arterial oxygen desaturations, increased inspiratory efforts, and sleep fragmentation, which have been associated with important long-term neurocognitive, metabolic, and cardiovascular consequences. Since inflammation, oxidative stress and endothelial dysfunction are key factors in the development of the morbid consequences of OSA, bone marrow-derived stem cells could be important modulators of the morbid phenotype by affording a protective role. This mini-review is focused on the recent data available on EPCs, VSELs, and MSCs in both animal models and patients with OSA.
Note: Reproducció del document publicat a:
It is part of: Frontiers In Neurology, 2012, vol. 3
Related resource:
ISSN: 1664-2295
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Files in This Item:
File Description SizeFormat 
630101.pdf521.19 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons