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https://hdl.handle.net/2445/138678
Title: | Potential role of adult stem cells in obstructive sleep apnea |
Author: | Almendros López, Isaac Carreras, Alba Montserrat Canal, José Ma. Gozal, David Navajas Navarro, Daniel Farré Ventura, Ramon |
Keywords: | Síndromes d'apnea del son Cèl·lules mare Sleep apnea syndromes Stem cells |
Issue Date: | 11-Jul-2012 |
Publisher: | Frontiers Media |
Abstract: | Adult stem cells are undifferentiated cells that can be mobilized from the bone marrow or other organs, home into injured tissues, and differentiate into different cell phenotypes to serve in a repairing capacity. Furthermore, these cells can respond to inflammation and oxidative stress by exhibiting immunomodulatory properties. The protective and reparative roles of mesenchymal stem cells (MSCs), very small embryonic-like stem cells (VSELs), and endothelial progenitor cells (EPCs) have primarily been examined and characterized in auto-immune and cardiovascular diseases. Obstructive sleep apnea (OSA) is a very prevalent disease (4-5% of adult population and 2-3% of children) characterized by an abnormal increase in upper airway collapsibility. Recurrent airway obstructions elicit arterial oxygen desaturations, increased inspiratory efforts, and sleep fragmentation, which have been associated with important long-term neurocognitive, metabolic, and cardiovascular consequences. Since inflammation, oxidative stress and endothelial dysfunction are key factors in the development of the morbid consequences of OSA, bone marrow-derived stem cells could be important modulators of the morbid phenotype by affording a protective role. This mini-review is focused on the recent data available on EPCs, VSELs, and MSCs in both animal models and patients with OSA. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fneur.2012.00112 |
It is part of: | Frontiers In Neurology, 2012, vol. 3 |
URI: | https://hdl.handle.net/2445/138678 |
Related resource: | https://doi.org/10.3389/fneur.2012.00112 |
ISSN: | 1664-2295 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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