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Title: Modulation of neuronal signal transduction and memory formation by synaptic zinc
Author: Sindreu Balet, Carlos
Storm, Daniel R.
Keywords: Zinc en l'organisme
Circuit neuronal
Transducció de senyal cel·lular
Zinc in the body
Neural circuitry
Cellular signal transduction
Issue Date: 9-Nov-2011
Publisher: Frontiers Media
Abstract: The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over 50 years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathways implicated in neuroplasticity, and others that shed some light on the elusive role of synaptic zinc in learning and memory. Recent behavioral studies using knock-out mice for the synapse-specific zinc transporter ZnT-3 indicate that vesicular zinc is required for the formation of memories dependent on the hippocampus and the amygdala, two brain centers that are prominently innervated by zinc-rich fibers. A common theme emerging from this research is the activity-dependent regulation of the Erk1/2 mitogen-activated-protein kinase pathway by synaptic zinc through diverse mechanisms in neurons. Here we discuss current knowledge on how synaptic zinc may play a role in cognition through its impact on neuronal signaling.
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It is part of: Frontiers in Behavioral Neuroscience, 2011, vol. 5
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ISSN: 1662-5153
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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