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http://hdl.handle.net/2445/138717
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DC Field | Value | Language |
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dc.contributor.author | Badiola Mateos, Maider | - |
dc.contributor.author | Hervera Abad, Arnau | - |
dc.contributor.author | Río Fernández, José Antonio del | - |
dc.contributor.author | Samitier i Martí, Josep | - |
dc.date.accessioned | 2019-08-26T11:01:11Z | - |
dc.date.available | 2019-08-26T11:01:11Z | - |
dc.date.issued | 2018-12-11 | - |
dc.identifier.issn | 2296-4185 | - |
dc.identifier.uri | http://hdl.handle.net/2445/138717 | - |
dc.description.abstract | Movement of skeletal-muscle fibers is generated by the coordinated action of several cells taking part within the locomotion circuit (motoneurons, sensory-neurons, Schwann cells, astrocytes, microglia, and muscle-cells). Failure s in any part of this circuit could impede or hinder coordinated muscle movement and cause a neu romuscular disease (NMD) or determine its severity. Studying fragments of the circuit cannot provide a comprehensive and complete view of the pathological process. We trace the historic developments of studies focused on in-vitro modeling of the spinal-locomotion circuit and how bioengineered innovative technologies show advantages for an accurate mimicking of hysiological conditions of spinal-locomotion circuit. New developments on compartmentalized microfluidic culture systems (cμFCS), the use of human induced pluripotent stem cells (hiPSCs) and 3D cell-cultures are analyzed. We finally address limitations of current study models and three main challenges on neuromuscular studies: (i) mimic the whole spinal-locomotion circuit including all cell-types involved and the evaluation of independent and interdependent roles of each one; (ii) mimic the neurodegenerative response of mature neurons in-vitro as it occurs in-vivo ; and (iii) develop, tune, implement, and combine cμFCS, hiPSC, and 3D-culture technologies to ultimately create patient-specific complete, translational, and reliable NMD in-vitro model. Overcoming these challenges would significantly facilitate understanding the events taking place in NMDs and accelerate the process of finding new therapies. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fbioe.2018.00194 | - |
dc.relation.ispartof | Frontiers in Bioengineering and Biotechnology, 2018, vol. 6, num. 194 | - |
dc.relation.uri | https://doi.org/10.3389/fbioe.2018.00194 | - |
dc.rights | cc-by (c) Badiola Mateos, Maider et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) | - |
dc.subject.classification | Malalties neuromusculars | - |
dc.subject.classification | Aparell locomotor | - |
dc.subject.classification | Bioenginyeria | - |
dc.subject.other | Neuromuscular diseases | - |
dc.subject.other | Musculoskeletal system | - |
dc.subject.other | Bioengineering | - |
dc.title | Challenges and future prospects on 3D in-vitro modeling of the neuromuscular circuit | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 685893 | - |
dc.date.updated | 2019-08-26T11:01:11Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30622944 | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) |
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685893.pdf | 841.21 kB | Adobe PDF | View/Open |
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