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http://hdl.handle.net/2445/138983
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DC Field | Value | Language |
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dc.contributor.author | Sanclemente, Gemma | - |
dc.contributor.author | Bodro, Marta | - |
dc.contributor.author | Cervera, Carlos | - |
dc.contributor.author | Linares, Laura | - |
dc.contributor.author | Cofán Pujol, Federico | - |
dc.contributor.author | Marco Reverté, Francesc | - |
dc.contributor.author | Bosch Mestres, Jordi | - |
dc.contributor.author | Oppenheimer Salinas, Federico | - |
dc.contributor.author | Dieckmann, Fritz | - |
dc.contributor.author | Moreno Camacho, Ma. Asunción | - |
dc.date.accessioned | 2019-09-02T09:55:56Z | - |
dc.date.available | 2019-09-02T09:55:56Z | - |
dc.date.issued | 2019-07-22 | - |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | http://hdl.handle.net/2445/138983 | - |
dc.description.abstract | Backgound: In recent years we have witnessed an increase in infections due to multidrug-resistant organisms in kidney transplant recipients (KTR). In our setting, we have observed a dramatic increase in infections caused by extended-spectrum betalactamase-producing (ESBL) Enterobacteriaceae in KTR. In 2014 we changed surgical prophylaxis from Cefazolin 2 g to Ertapenem 1 g. Methods: We compared bacterial infections and their resistance phenotype during the first post-transplant month with an historical cohort collected during 2013 that had received Cefazolin. Results: During the study period 110 patients received prophylaxis with Cefazolin and 113 with Ertapenem. In the Ertapenem cohort we observed a non-statistically significant decrease in the percentage of early bacterial infection from 57 to 47%, with urine being the most frequent source in both. The frequency of infections caused by Enterobacteriaceae spp. decreased from 64% in the Cefazolin cohort to 36% in the Ertapenem cohort (p = 0.005). In addition, percentage of ESBL-producing strains decreased from 21 to 8% of all Enterobacteriaceae isolated (p = 0.015). After adjusted in multivariate Cox regression analysis, male sex (HR 0.16, 95%CI: 0.03–0.75), cefazolin prophylaxis (HR 4.7, 95% CI: 1.1–22.6) and acute rejection (HR 14.5, 95% CI: 1.3–162) were associated to ESBL- producing Enterobacteriaceae infection. Conclusions: Perioperative antimicrobial prophylaxis with a single dose of Ertapenem in kidney transplant recipients reduced the incidence of early infections due to ESBL-producing Enterobacteriaceae without increasing the incidence of other multidrug-resistant microorganisms or C. difficile. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s12882-019-1461-4 | - |
dc.relation.ispartof | BMC Nephrology, 2019, vol. 20 | - |
dc.relation.uri | http://dx.doi.org/10.1186/s12882-019-1461-4 | - |
dc.rights | cc by (c) Sanclemente et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Enterobacteriàcies | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Enterobacteriaceae | - |
dc.title | Perioperative prophylaxis with ertapenem reduced infections caused by extended-spectrum betalactamase-producting Enterobacteriaceae after kidney transplantation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 693626 | - |
dc.date.updated | 2019-08-02T18:00:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31331289 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Medicina) Articles publicats en revistes (Fonaments Clínics) |
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SanclementeG_BMC_Nephrol_2019.pdf | 621.82 kB | Adobe PDF | View/Open |
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