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dc.contributor.authorSanclemente, Gemma-
dc.contributor.authorBodro, Marta-
dc.contributor.authorCervera, Carlos-
dc.contributor.authorLinares, Laura-
dc.contributor.authorCofán Pujol, Federico-
dc.contributor.authorMarco Reverté, Francesc-
dc.contributor.authorBosch Mestres, Jordi-
dc.contributor.authorOppenheimer Salinas, Federico-
dc.contributor.authorDieckmann, Fritz-
dc.contributor.authorMoreno Camacho, Ma. Asunción-
dc.description.abstractBackgound: In recent years we have witnessed an increase in infections due to multidrug-resistant organisms in kidney transplant recipients (KTR). In our setting, we have observed a dramatic increase in infections caused by extended-spectrum betalactamase-producing (ESBL) Enterobacteriaceae in KTR. In 2014 we changed surgical prophylaxis from Cefazolin 2 g to Ertapenem 1 g. Methods: We compared bacterial infections and their resistance phenotype during the first post-transplant month with an historical cohort collected during 2013 that had received Cefazolin. Results: During the study period 110 patients received prophylaxis with Cefazolin and 113 with Ertapenem. In the Ertapenem cohort we observed a non-statistically significant decrease in the percentage of early bacterial infection from 57 to 47%, with urine being the most frequent source in both. The frequency of infections caused by Enterobacteriaceae spp. decreased from 64% in the Cefazolin cohort to 36% in the Ertapenem cohort (p = 0.005). In addition, percentage of ESBL-producing strains decreased from 21 to 8% of all Enterobacteriaceae isolated (p = 0.015). After adjusted in multivariate Cox regression analysis, male sex (HR 0.16, 95%CI: 0.03–0.75), cefazolin prophylaxis (HR 4.7, 95% CI: 1.1–22.6) and acute rejection (HR 14.5, 95% CI: 1.3–162) were associated to ESBL- producing Enterobacteriaceae infection. Conclusions: Perioperative antimicrobial prophylaxis with a single dose of Ertapenem in kidney transplant recipients reduced the incidence of early infections due to ESBL-producing Enterobacteriaceae without increasing the incidence of other multidrug-resistant microorganisms or C. difficile.-
dc.format.extent10 p.-
dc.publisherBioMed Central-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofBMC Nephrology, 2019, vol. 20-
dc.rightscc by (c) Sanclemente et al., 2019-
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationTrasplantament renal-
dc.subject.otherKidney transplantation-
dc.titlePerioperative prophylaxis with ertapenem reduced infections caused by extended-spectrum betalactamase-producting Enterobacteriaceae after kidney transplantation-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Fonaments Clínics)

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