Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/139400
Title: | Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells |
Author: | Thottacherry, Joseph Jose Kosmalska, Anita Joanna Kumar, Amit Vishen, Amit S. Elosegui Artola, Alberto Pradhan, Susav Sharma, Sumit Singh, Parvinder P. Guadamillas, Marta C. Chaudhary, Natasha Vishwakarma, Ram Trepat Guixer, Xavier Pozo, Miguel A. del Parton, Robert G. Rao, Madan Pullarkat, Pramod Roca-Cusachs Soulere, Pere Mayor, Satyajit |
Keywords: | Biologia molecular Transport biològic Membranes (Biologia) Molecular biology Biological transport Membranes (Biology) |
Issue Date: | 11-Oct-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Plasma membrane tension regulates many key cellular processes. It is modulated by, and can modulate, membrane trafficking. However, the cellular pathway(s) involved in this interplay is poorly understood. Here we find that, among a number of endocytic processes operating simultaneously at the cell surface, a dynamin independent pathway, the CLIC/GEEC (CG) pathway, is rapidly and specifically upregulated upon a sudden reduction of tension. Moreover, inhibition (activation) of the CG pathway results in lower (higher) membrane tension. However, alteration in membrane tension does not directly modulate CG endocytosis. This requires vinculin, a mechano-transducer recruited to focal adhesion in adherent cells. Vinculin acts by controlling the levels of a key regulator of the CG pathway, GBF1, at the plasma membrane. Thus, the CG pathway directly regulates membrane tension and is in turn controlled via a mechano-chemical feedback inhibition, potentially leading to homeostatic regulation of membrane tension in adherent cells. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-06738-5 |
It is part of: | Nature Communications, 2018, vol. 9, p. 4217 |
URI: | http://hdl.handle.net/2445/139400 |
Related resource: | https://doi.org/10.1038/s41467-018-06738-5 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
687405.pdf | 4.32 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License