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http://hdl.handle.net/2445/139899
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DC Field | Value | Language |
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dc.contributor.author | Andrés Benito, Pol | - |
dc.contributor.author | Domínguez, Raúl | - |
dc.contributor.author | Colomina Soler, M. J. (María José) | - |
dc.contributor.author | Llorens Torres, Franc | - |
dc.contributor.author | Povedano, Mònica | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.date.accessioned | 2019-09-12T15:13:26Z | - |
dc.date.available | 2019-09-12T15:13:26Z | - |
dc.date.issued | 2018-09-13 | - |
dc.identifier.issn | 1945-4589 | - |
dc.identifier.uri | http://hdl.handle.net/2445/139899 | - |
dc.description.abstract | Abstract Amyotrophic lateral sclerosis (ALS) has variable clinical course and fatal outcome. Since inflammation plays a role in the pathogenesis of ALS, chitinase-3-like protein 1 or YKL40 has been assessed as putative biomarker of disease progression. YKL40 mRNA levels are increased in anterior horn of the spinal cord (P=0.004) in sporadic ALS (sALS) cases when compared with age-matched controls. These correlate with increased mRNA expression of microglial markers AIF1 and CD68 in the spinal cord in sALS (P=0.044 and P=0.000, respectively). YKL40 mRNA and protein expression had a tendency to increase in post-mortem frontal cortex area 8 (P=0.06 and P=0.08, respectively). Yet YKL40 immunoreactivity is restricted to a subpopulation of astrocytes in these regions. YKL40 protein levels, as revealed by enzyme-linked immunosorbent assay (ELISA), are significantly increased in the CSF in sALS (n=86) compared with age-matched controls (n=21) (P=0.045). Higher levels are found in patients with fast progression when compared with patients with slow and normal progression (P=0.008 and P=0.004, respectively), and correlates with ALS-FRS-R slope (P=0.000). Additionally, increased protein levels of neurofilament light chain (NF-L) are also found in sALS (P=0.000); highest values are found in patients with fast progression when compared with cases with slow and normal progression (P=0.005 and P=0.000, respectively), and also correlate with ALS-FRS-R slope (P=0.000). Pearson's correlation test linked positively the increased levels of YKL40 with increased NF-L levels (P=0.013). These data point to YKL40 and NF-L protein levels in the CSF as a good biomarker combination of disease progression in sALS. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Impact Journals | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.18632/aging.101551 | - |
dc.relation.ispartof | Aging, 2018, vol. 10, num. 9, p. 2367-2382 | - |
dc.relation.uri | https://doi.org/10.18632/aging.101551 | - |
dc.rights | cc-by (c) Andrés Benito, Pol et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Esclerosi lateral amiotròfica | - |
dc.subject.classification | Líquid cefalorraquidi | - |
dc.subject.classification | Medul·la espinal | - |
dc.subject.other | Amyotrophic lateral sclerosis | - |
dc.subject.other | Cerebrospinal fluid | - |
dc.subject.other | Spinal cord | - |
dc.title | YKL40 in sporadic amyotrophic lateral sclerosis: cerebrospinal fluid levels as a prognosis marker of disease progression | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 683301 | - |
dc.date.updated | 2019-09-12T15:13:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30215603 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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683301.pdf | 1.71 MB | Adobe PDF | View/Open |
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