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Title: Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology
Author: Alonso-Andrés, Patricia
Albasanz, José Luis
Ferrer, Isidro (Ferrer Abizanda)
Martín, Mairena
Keywords: Malaltia d'Alzheimer
Lòbul frontal
Lòbul temporal
Alzheimer's disease
Frontal lobe
Temporal lobe
Issue Date: 1-Nov-2018
Publisher: Wiley
Abstract: Adenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal (PC) and temporal (TC) cortices at different stages of disease progression in Alzheimer's disease (AD) and in age-matched controls. Significantly decreased levels of adenosine, guanosine, hypoxanthine, and xanthine, and apparently less inosine, are found in FC from the early stages of AD; PC and TC show an opposing pattern, as adenosine, guanosine, and inosine are significantly increased at least at determinate stages of AD whereas hypoxanthine and xanthine levels remain unaltered. 5'-NT is reduced in membranes and cytosol in FC mainly at early stages but not in PC, and only at advanced stages in cytosol in TC. ADA activity is decreased in AD when considered as a whole but increased at early stages in TC. Finally, PNP activity is increased only in TC at early stages. Purine metabolism alterations occur at early stages of AD independently of neurofibrillary tangles and β-amyloid plaques. Alterations are stage- and regiondependent, the latter showing opposite patterns in FC compared with PC and TC. Adenosine is the most affected of the assessed purines. Key words: Adenosine, Alzheimer's disease, cerebral cortex, purine metabolism.
Note: Versió postprint del document publicat a:
It is part of: Brain Pathology, 2018, vol. 28, num. 6, p. 933-946
Related resource:
ISSN: 1015-6305
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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