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Title: Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies
Author: Santpere Baró, Gabriel
Garcia Esparcia, Paula
Andrés Benito, Pol
Lorente-Galdos, Belen
Navarro i Cuartiellas, Arcadi, 1969-
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Lòbul frontal
Demència amb cossos de Lewy
Malaltia de Parkinson
Frontal lobe
Lewy body dementia
Parkinson's disease
Issue Date: May-2018
Publisher: Wiley
Abstract: The present study investigates global transcriptional changes in frontal cortex area 8 in incidental Lewy Body disease (iLBD), Parkinson disease (PD) and Dementia with Lewy bodies (DLB). We identified different co-expressed gene sets associated with disease stages, and gene ontology categories enriched in gene modules and differentially expressed genes including modules or gene clusters correlated to iLBD comprising upregulated dynein genes and taste receptors, and down-regulated innate inflammation. Focusing on DLB, we found modules with genes significantly enriched in functions related to RNA and DNA production, mitochondria and energy metabolism, purine metabolism, chaperone and protein folding system, and synapses and neurotransmission (particularly the GABAergic system). The expression of more than fifty selected genes was assessed with RT-qPCR. Our findings provide, for the first time, evidence of molecular cortical alterations in iLBD and involvement of several key metabolic pathways and gene hubs in DLB which may underlie cognitive impairment and dementia. Key words: Lewy body diseases, dementia with Lewy bodies, cerebral cortex, transcriptome, mitochondria, synapses, neurotransmission, GABA, purine metabolism, chaperones, dynein, axonema, taste receptors.
Note: Versió postprint del document publicat a:
It is part of: Brain Pathology, 2018, vol. 28, num. 3, p. 315-333
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ISSN: 1015-6305
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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