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Title: Sixty years old is the breakpoint of human frontal cortex aging
Author: Cabré, Rosanna
Naudi, Alba
Domínguez González, Mayelín
Ayala, Victòria
Jove, Mariona
Mota-Martorell, Natalia
Piñol Ripoll, Gerard
Gil-Villar, Maria Pilar
Rué, Montserrat
Portero Otin, Manuel
Ferrer, Isidro (Ferrer Abizanda)
Pamplona, Reinald
Keywords: Envelliment
Lòbul frontal
Frontal lobe
Issue Date: 1-Feb-2017
Publisher: Elsevier B.V.
Abstract: Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional throughout a healthy adult lifespan, yet the mechanisms that maintain function and protect against neurodegenerative processes during aging are unknown. Here we show that protein oxidative and glycoxidative damage significantly increases during human brain aging, with a breakpoint at 60 years old. This trajectory is coincident with a decrease in the content of the mitochondrial respiratory chain complex I to IV. We suggest that the deterioration in oxidative stress homeostasis during aging induces an adaptive response of stress resistance mechanisms based on the sustained expression of REST, and increased or decreased expression of Akt and mTOR, respectively, over the adult lifespan in order to preserve cell neural survival and function.
Note: Versió postprint del document publicat a:
It is part of: Free Radical Biology and Medicine, 2017, vol. 103, p. 14-22
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ISSN: 0891-5849
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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