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http://hdl.handle.net/2445/141119
Title: | Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition |
Author: | Lin, Crystal Travis, Ruth C. Appleby, Paul N. Tipper, Sarah Weiderpass, Elisabete Chang Claude, Jenny Gram, Inger T. Kaaks, Rudolf Kiemeney, Lambertus A. L. M. Ljungberg, Börje Tumino, Rosario Tjønneland, Anne Roswall, Nina Overvad, Kim Boutron-Ruault, Marie-Christine Manciniveri, Francesca Romana Severi, Gianluca Trichopoulou, Antonia Masala, Giovanna Sacerdote, Carlotta Agnoli, Claudia Panico, Salvatore Bueno de Mesquita, H. Bas Peeters, Petra H. M. Salamanca Fernández, Elena Chirlaque, María Dolores Ardanaz, Eva Dorronsoro, Miren Menéndez, Virginia Luján Barroso, Leila Liedberg, Fredrik Freisling, Heinz Gunter, Marc J. Aune, Dagfinn Cross, Amanda J. Riboli, Elio Key, Timothy J. Perez Cornago, Aurora |
Keywords: | Càncer de bufeta Tumors Factors de risc en les malalties Bladder cancer Tumors Risk factors in diseases |
Issue Date: | 4-Jul-2018 |
Publisher: | Wiley |
Abstract: | Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/ijc.31650 |
It is part of: | International Journal of Cancer, 2018, vol. 143, p. 2351-2358 |
URI: | http://hdl.handle.net/2445/141119 |
Related resource: | https://doi.org/10.1002/ijc.31650 |
ISSN: | 0020-7136 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) |
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