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http://hdl.handle.net/2445/141217
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DC Field | Value | Language |
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dc.contributor.author | Welz, Patrick-Simon | - |
dc.contributor.author | Zinna, Valentina M. | - |
dc.contributor.author | Symeonidi, Aikaterini | - |
dc.contributor.author | Koronowski, Kevin B. | - |
dc.contributor.author | Kinouchi, Kenichiro | - |
dc.contributor.author | Smith, Jacob G. | - |
dc.contributor.author | Marín Guillén, Inés | - |
dc.contributor.author | Castellanos, Andrés | - |
dc.contributor.author | Furrow, Stephen | - |
dc.contributor.author | Aragón, Ferrán | - |
dc.contributor.author | Crainiciuc, Georgiana | - |
dc.contributor.author | Prats, Neus | - |
dc.contributor.author | Martín Caballero, Juan | - |
dc.contributor.author | Hidalgo, Andrés | - |
dc.contributor.author | Sassone-Corsi, Paolo | - |
dc.contributor.author | Aznar Benitah, Salvador | - |
dc.date.accessioned | 2019-09-30T07:54:13Z | - |
dc.date.available | 2020-05-30T05:10:27Z | - |
dc.date.issued | 2019-05-30 | - |
dc.identifier.uri | http://hdl.handle.net/2445/141217 | - |
dc.description.abstract | Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues. | - |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.cell.2019.05.009 | - |
dc.relation.ispartof | Cell, 2019, vol. 177, num. 6, p. 1436-1447 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.cell.2019.05.009 | - |
dc.rights | cc by-nc-nd (c) Welz et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Ritmes circadiaris | - |
dc.subject.classification | Fisiologia | - |
dc.subject.other | Circadian rhythms | - |
dc.subject.other | Physiology | - |
dc.title | BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2019-09-16T13:35:42Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/713673/EU//INPhINIT | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31150620 | - |
dc.identifier.pmid | 31398328 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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BMAL1-Driven.pdf | 6.97 MB | Adobe PDF | View/Open |
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