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Title: Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
Author: Font, M. Angels
Fernández, Alex (Fernández Solanas)
Carvajal, Ana
Gámez, Cristina
Badimón, Lina, 1953-
Slevin, Mark
Krupinski, Jerzy
Keywords: Inflamació
Artèries caròtides
Diagnòstic per la imatge
Carotid artery
Diagnostic imaging
Issue Date: 1-Jan-2009
Publisher: Frontiers in Bioscience
Abstract: It is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake values were calculated based on maximum standardized uptake value (SUV) and corresponding uptake ratios. We confirmed by CD68 macrophage staining that FDG accumulation corresponds to active inflammation (R=0.8 p less than 0.005). We found significant correlation between the FDG-uptake in the carotids scheduled for CEA and contralateral carotids with low to moderate stenosis (R=0.9 p less than 0.001). The FDG uptake ratio in the contralateral arteries remained stable on the follow-up imaging (1.15+/-0.2 vs. 1.14+/-0.1, R=0.7 p=0.006). We did not find correlation between FDG uptake and symptomatic or asymptomatic patients, degree of carotid stenosis and vascular risk factors. This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis.
Note: Versió postprint del document publicat a:
It is part of: Frontiers in Bioscience-Landmark Edition, 2009, vol. 14, p. 3352-3360
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ISSN: 1093-9946
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Medicina)

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