Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/141728
Title: | Lipid profile in human frontal cortex is sustained throught healthy adult lifde span to decay at advanced ages |
Author: | Cabré, Rosanna Naudi, Alba Domínguez González, Mayelín Jove, Mariona Ayala, Victòria Mota-Martorell, Natalia Portero-Otin, Manuel Ferrer, Isidro (Ferrer Abizanda) Pamplona, Reinald Pradas, Irene Nogueras, Lara Rué, Montserrat |
Keywords: | Envelliment Metabolisme Àcids grassos Lòbul frontal Aging Metabolism Fatty acids Frontal lobe |
Issue Date: | 9-May-2018 |
Publisher: | Gerontological Society of America |
Abstract: | Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the structural and functional integrity of neural cell membranes, the generation of lipid signaling mediators, and the chemical reactivity of acyl chains. The present study analyzes the profile of lipid fatty acid composition of membranes of human frontal cortex area 8 in individuals ranging from 40 to 90 years old. Different components involved in polyunsaturated fatty acid biosynthesis pathways, as well as adaptive defense mechanisms involved in the lipid-mediated modulation of inflammation, are also assessed. Our results show that the lipid profile in human frontal cortex is basically preserved through the adult life span to decay at advanced ages, which is accompanied by an adaptive proactive anti-inflammatory response possibly geared to ensuring cell survival and function. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1093/gerona/glx164 |
It is part of: | Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2018, vol. 73, num. 6, p. 703-710 |
URI: | https://hdl.handle.net/2445/141728 |
Related resource: | https://doi.org/10.1093/gerona/glx164 |
ISSN: | 1079-5006 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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