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Title: Reelin expression in Creutzfeldt-Jakob disease and experimental models of transmissible spongiform encephalopathies
Author: Mata Rodríguez, Agata
Urrea Zazurca, Laura
Vilches Saez, Silvia
Llorens Torres, Franc
Thüne, Katrin
Espinosa, Juan Carlos
Andréoletti, Olivier
Sevillano, Alejandro M.
Torres, Juan Maria
Rodríguez Requena, Jesús
Zerr, Inga
Ferrer, Isidro (Ferrer Abizanda)
Gavín Marín, Rosalina
Río Fernández, José Antonio del
Keywords: Metabolisme
Malaltia de Creutzfeldt-Jakob
Matriu extracel·lular
Teixit nerviós
Malalties per prions
Creutzfeldt-Jakob disease
Extracellular matrix
Nerve tissue
Prion diseases
Issue Date: 1-Oct-2017
Publisher: Humana Press.
Abstract: Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule, in turn mediated by binding Reelin to its receptors. Altered expression and glycosylation patterns of Reelin in cerebrospinal and cortical extracts have been reported in Alzheimer's disease. However, putative changes in Reelin are not described in natural prionopathies or experimental models of prion infection or toxicity. With this is mind, in the present study, we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection. However, changes in Reelin expression appeared only at late terminal stages of the disease, which prevent their use as an efficient diagnostic biomarker. In addition, increased Reelin in CJD and in in vitro models does not correlate with Dab1 phosphorylation, indicating failure in its intracellular signaling. Overall, these findings widen our understanding of the putative changes of Reelin in neurodegeneration.
Note: Versió postprint del document publicat a:
It is part of: Molecular Neurobiology, 2017, vol. 54, num. 8, p. 6412-6425
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ISSN: 0893-7648
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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