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http://hdl.handle.net/2445/141815
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DC Field | Value | Language |
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dc.contributor.author | Lachén Montes, Mercedes | - |
dc.contributor.author | González Morales, Andrea | - |
dc.contributor.author | Iloro, Ibon | - |
dc.contributor.author | Elortza, Felix | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.contributor.author | Gveric, Djordje | - |
dc.contributor.author | Fernández Irigoyen, Joaquín | - |
dc.contributor.author | Santamaría, Enrique | - |
dc.date.accessioned | 2019-10-07T18:12:29Z | - |
dc.date.available | 2020-01-01T06:10:20Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | http://hdl.handle.net/2445/141815 | - |
dc.description.abstract | Olfactory dysfunction is one of the earliest features in Lewy-type alphasynucleinopathies (LTS) such as Parkinson´s disease (PD). However, the underlying molecular mechanisms associated to smell impairment are poorly understood. Applying mass spectrometry-based quantitative proteomics in postmortem olfactory bulbs (OB) across limbic, early-neocortical, and neocortical LTS stages of parkinsonian subjects, a proteostasis impairment was observed, identifying 268 differentially expressed proteins between controls and PD phenotypes. In addition, network-driven proteomics revealed a modulation in ERK1/2, MKK3/6, and PDK1/PKC signalling axis. Moreover, a crossdisease study of selected olfactory molecules in sporadic Alzheimer's disease (AD) cases, revealed different protein derangements in the modulation of Secretagogin (SCGN), Calcyclin binding protein (CACYBP), and Glucosamine 6 phosphate isomerase 2 (GNPDA2) between PD and AD. An inverse correlation between GNPDA2 and α-synuclein protein levels was also reflected in PD cerebrospinal fluid (CSF). Interestingly, PD patients exhibited significantly lower serum GNPDA2 levels than controls (n=82/group). Our study provides important avenues for understanding the OB proteostasis imbalance in PD, deciphering mechanistic clues to the equivalent smell deficits observed in AD and PD pathologies. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2018.09.018 | - |
dc.relation.ispartof | Neurobiology of Aging, 2019, vol. 73, p. 123-134 | - |
dc.relation.uri | https://doi.org/10.1016/j.neurobiolaging.2018.09.018 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Olfacte | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.classification | Proteòmica | - |
dc.subject.classification | Biologia de sistemes | - |
dc.subject.other | Smell | - |
dc.subject.other | Parkinson's disease | - |
dc.subject.other | Proteomics | - |
dc.subject.other | Systems biology | - |
dc.title | Unveiling the olfactory proteostatic dissangement in Parkinson's disease by proteome-wide profiling | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 689447 | - |
dc.date.updated | 2019-10-07T18:12:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30342273 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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689447.pdf | 3.71 MB | Adobe PDF | View/Open |
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