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http://hdl.handle.net/2445/141852
Title: | Role of cellular prion protein in interneuronal amyloid transmission |
Author: | Río Fernández, José Antonio del Ferrer, Isidro (Ferrer Abizanda) Gavín Marín, Rosalina |
Keywords: | Amiloïdosi Pèptids Metabolisme Alfa-sinucleïna Proteïnes Amyloidosis Peptides Metabolism Alpha-synuclein Proteins |
Issue Date: | 1-Jun-2018 |
Publisher: | Elsevier Ltd |
Abstract: | Several studies have indicated that certain misfolded amyloids composed of tau, β-amyloid or α-synuclein can be transferred from cell to cell, suggesting the contribution of mechanisms reminiscent of those by which infective prions spread through the brain. This process of a 'prion-like' spreading between cells is also relevant as a novel putative therapeutic target that could block the spreading of proteinaceous aggregates throughout the brain which may underlie the progressive nature of neurodegenerative diseases. The relevance of β-amyloid oligomers and cellular prion protein (PrPC) binding has been a focus of interest in Alzheimer's disease (AD). At the molecular level, β-amyloid/PrPC interaction takes place in two differently charged clusters of PrPC. In addition to β-amyloid, participation of PrPC in α-synuclein binding and brain spreading also appears to be relevant in α-synucleopathies. This review summarizes current knowledge about PrPC as a putative receptor for amyloid proteins and the physiological consequences of these interactions. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.pneurobio.2018.03.001 |
It is part of: | Progress in Neurobiology, 2018, vol. 165-167, p. 87-102 |
URI: | http://hdl.handle.net/2445/141852 |
Related resource: | https://doi.org/10.1016/j.pneurobio.2018.03.001 |
ISSN: | 0301-0082 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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