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http://hdl.handle.net/2445/141853
Title: | Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells |
Author: | Biagioli, Marta Pinto, Milena Cesselli, Daniela Zaninello, Marta Lazarevic, Dejan Roncaglia, Paola Simone, Roberto Vlachouli, Christina Plessy, Charles Bertin, Nicolas Beltrami, Antonio Kobayashi, Kazuto Gallo, Vittorio Santoro, Claudio Ferrer, Isidro (Ferrer Abizanda) Rivella, Stefano Beltrami, Carlo Alberto Carninci, Piero Raviola, Elio Gustincich, Stefano |
Keywords: | Neuròglia Metabolisme Neurones Citologia Neuroglia Metabolism Neurons Cytology |
Issue Date: | 8-Sep-2009 |
Publisher: | National Academy of Sciences |
Abstract: | The mesencephalic dopaminergic (mDA) cell system is composed of two major groups of projecting cells in the substantia nigra (SN) (A9 neurons) and the ventral tegmental area (VTA) (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Their selective degeneration leads to Parkinson's disease. Here, we report that gene expression analysis of A9 dopaminergic neurons (DA) identifies transcripts for alpha- and beta-chains of hemoglobin (Hb). Globin immunoreactivity decorates the majority of A9 DA, a subpopulation of cortical and hippocampal astrocytes and mature oligodendrocytes. This pattern of expression was confirmed in different mouse strains and in rat and human. We show that Hb is expressed in the SN of human postmortem brain. By microarray analysis of dopaminergic cell lines overexpressing alpha- and beta-globin chains, changes in genes involved in O(2) homeostasis and oxidative phopshorylation were observed, linking Hb expression to mitochondrial function. Our data suggest that the most famed oxygen-carrying globin is not exclusively restricted to the blood, but it may play a role in the normal physiology of the brain and neurodegenerative diseases. |
Note: | Reproducció del document publicat a: https://doi.org/10.1073/pnas.0813216106 |
It is part of: | Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2009, vol. 106, num. 36, p. 15454-15459 |
URI: | http://hdl.handle.net/2445/141853 |
Related resource: | https://doi.org/10.1073/pnas.0813216106 |
ISSN: | 0027-8424 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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